Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis

Dam Kim, Soo Kyung Cho, Chan Bum Choi, Jung Yoon Choe, Won Tae Chung, Seung Jae Hong, Jae Bum Jun, Young Ok Jung, Tae Hwan Kim, Tae Jong Kim, Hye Soon Lee, Joo Hyun Lee, Jisoo Lee, Shin Seok Lee, Dae Hyun Yoo, Bo Young Yoon, Jin Woo Song, Sang Cheol Bae, Yoon Kyoung Sung

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39 Scopus citations


To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities. After comparing the characteristics of the groups at enrollment, mortalities were compared using the log-rank test. To explore the impact of ILD on mortality, Cox proportional hazard models were used. Sixty-four patients (1.8%) were identified with ILD. Male and older patients were more common in the ILD group. During a mean follow-up of 24 months, 6 patients (9.4%) in the ILD group and 25 patients (0.7%) in the non-ILD group died; the survival rate was significantly worse in the ILD group (p < 0.01). On adjusted analysis, ILD was significantly associated with increased mortality (HR 7.89, CI 3.16–19.69, p < 0.01); the risk of death in patients with ILD was even higher than in patients with cardiovascular disease (CVD, HR 4.10, CI 1.79–9.37, p < 0.01). The prevalence of ILD was 1.8% in Korean patients with RA. ILD is a major risk factor for mortality in patients with RA.

Original languageEnglish
Pages (from-to)1735-1745
Number of pages11
JournalRheumatology International
Issue number10
StatePublished - 1 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017, Springer-Verlag GmbH Germany.


  • Interstitial lung disease
  • Mortality
  • Prevalence
  • Rheumatoid arthritis


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