@article{3093fd86616b4ee38a669cc0a29d6101,
title = "Impact of an education program for caregivers of patients with Alzheimer{\textquoteright}s disease on treatment discontinuation and compliance in Korea",
abstract = "Background and Purpose Reportedly 30–50% of patients being treated for chronic illnesses do not adhere to their medication regimen. We assessed the impact of a nurse-led education program for caregivers of Korean de novo Alzheimer{\textquoteright}s disease patients who had newly been prescribed donepezil. Methods This multicenter study analyzed 93 participants in a caregiver education group and 92 participants in a caregiver no-education group. At every visit up to the end of the study (1 year), caregivers in the education group were given educational brochures regarding Alzheimer{\textquoteright}s disease and the efficacy and adverse events of donepezil treatment. The primary endpoint was the discontinuation rate of donepezil treatment during the 1-year observation period. The secondary endpoints included the effect of education on compliance with donepezil treatment assessed at each visit using a clinician rating scale (CRS) and visual analog scale (VAS), and changes from baseline in cognitive assessment tests. Results The donepezil discontinuation rates at 1 year were 5.38% (5/93) and 6.52% (6/92) in the caregiver education and no-education groups, respectively (p=0.742). No significant between-group differences in donepezil compliance rates on the CRS and VAS were observed, but significant changes were observed in some cognitive tests from baseline to the end of the study. Conclusions Caregiver education had no significant effect on treatment discontinuation, but this may have been due to the low severity of cognitive impairment among the included population at baseline. In addition, the low discontinuation rates meant that no significant difference in treatment compliance was observed.",
keywords = "Alzheimer{\textquoteright}s disease, Caregiver education, Dementia, Korea, Treatment compliance",
author = "Kim, {Hee Jin} and Shim, {Yong S.} and Park, {Kee Hyung} and Lee, {Chan Nyoung} and San Jung and Yoon, {Soo Jin} and Jeong, {Seul Ki} and Jeong, {Jee Hyang} and Choi, {Seong Hye} and Kim, {Eun Joo} and Jang, {Jae Won} and Kyunghun Kang and Youngsoon Yang and Sangyun Kim",
note = "Funding Information: This study was funded by Eisai Korea Inc. The funding body had a role in study design, data collection, data analysis, interpretation of data, and in writing the manuscript. We thank Jin Ran Kim of MSL, Eisai Korea for consultation and medical writing support. The authors wish to thank Keyra Martinez Dunn, MD, of Edanz Pharma for providing medical writing services, which were funded by Eisai Korea Inc. The following institutions participated in this study: College of Medicine, Hanyang University, Seoul, Korea; The Catholic University of Korea, Seoul, Korea; College of Medicine, Gacheon University, Seoul, Korea; Korea University Anam Hospital, Seoul, Korea; Hallym University Medical Center, Kangnam Sacred Heart Hospital, Seoul, Korea; Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea; Chonbuk University School of Medicine, Jeonju, Korea; Ewha Womans University, Seoul, Korea; Inha University School of Medicine, Incheon, Korea; Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea; Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea; School of Medicine, Kyungpook National University, Daegu, Korea; SVH Medical Center, Seoul, Korea; Seoul National University Bundang Hospital, Seongnam, Korea; and Seoul National University College of Medicine, Seoul, Korea. Funding Information: This study was funded by Eisai Korea Inc. The funding body had a role in study design, data collection, data analysis, interpretation of data, and in writing the manuscript. Publisher Copyright: {\textcopyright} 2021 Korean Neurological Association.",
year = "2021",
month = jul,
doi = "10.3988/jcn.2021.17.3.368",
language = "English",
volume = "17",
pages = "368--375",
journal = "Journal of Clinical Neurology (Korea)",
issn = "1738-6586",
publisher = "Korean Neurological Association",
number = "3",
}