@article{71ffb0f28a33449cb112e3414dbe5cb8,
title = "Impact of a multidomain lifestyle intervention on regional spontaneous brain activity",
abstract = "In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of multidomain lifestyle intervention on regional homogeneity (ReHo) in resting-state functional brain magnetic resonance imaging (MRI) data. Of 152 participants aged 60–79 years without dementia assigned to either facility-based multidomain intervention (FMI), home-based MI, or controls, we analyzed 56 scanned MRIs at baseline and 24 weeks. ReHo values from regions with significant longitudinal changes were compared between the intervention and control groups and their correlations with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) or serum brain-derived neurotrophic factor (BDNF) were evaluated. ReHo values in the left medial orbitofrontal gyrus and right superior parietal lobule were increased [p = 0.021, correlated positively with serum BDNF changes (r = 0.504, p = 0.047)] and decreased [p = 0.021, correlated negatively with changes in the total (r = −0.509, p = 0.044) and attention (r = −0.562, p = 0.023). RBANS], respectively, in the participants assigned to the FMI group than those of the controls. Our results suggest that facility-based group preventive strategies may have cognitive benefits through neuroplastic changes in functional processing circuits in the brain areas which play a crucial role in the adaptive learning and internally directed cognition.",
keywords = "SUPERBRAIN, brain activity, cognition, dementia, intervention, lifestyle, prevention, regional homogeneity",
author = "Moon, {So Young} and Shin, {Seong A.} and Jeong, {Jee Hyang} and Hong, {Chang Hyung} and Park, {Yoo Kyoung} and Na, {Hae Ri} and Song, {Hong Sun} and Park, {Hee Kyung} and Muncheong Choi and Lee, {Sun Min} and Chun, {Buong O.} and Lee, {Jong Min} and Choi, {Seong Hye}",
note = "Funding Information: This work was supported by grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center (KDRC), funded by the Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea (HU20C0198, and HU21C0016). The funders had no role in the study design, data collection, analysis, interpretation of data, writing of the report, or decision to submit the manuscript for publication. Funding Information: SM received a research grant from Hyundai Pharmaceutical Co. Ltd. CH receives research support from Eisai Korea Inc. JJ receives research grants from Chong Kun Dang Pharmaceutical Corp., Jeil Pharmaceutical Co. Ltd., and Kuhnil Pharmaceutical Co. Ltd., and consults for PeopleBio Co. Ltd. SM, CH, JJ, YP, HN, and SC are shareholders of Rowan Inc. YP consults for Pulmuone Co. Ltd. HN consults for Hyundai Pharmaceutical Co. Ltd. SC consults for Hyundai Pharmaceutical Co. Ltd. and PeopleBio Co. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher Copyright: Copyright {\textcopyright} 2022 Moon, Shin, Jeong, Hong, Park, Na, Song, Park, Choi, Lee, Chun, Lee and Choi.",
year = "2022",
month = jul,
day = "28",
doi = "10.3389/fnagi.2022.926077",
language = "English",
volume = "14",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",
}