Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte

Goo Taeg Oh; Sang Bae Han; Hwan Mook Kim; Man Woo Han; Ick Dong Yoo

doi:10.1007/BF02974118

Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte

Goo Taeg Oh, Sang Bae Han, Hwan Mook Kim, Man Woo Han, Ick Dong Yoo

Department of Life Science

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Phellinus linteus was examined on its immunostimulating activities using an in vitro immunization and plaque forming cell assay. When lymphocytes were exposed to the extract of Phellinus linteus, the number of antibody forming cell was increased. In in vitro plaque forming cell assay, the immunostimulating effect was about 4.8 and 5.0 times of unimmunized control in polyclonal and T-independent antibody response, respectively. Especially, Phellinus linteus significantly increased the antigenicity of TNP-LPS used as T-independent antigen. But Phellinus linteus did not show a mitogenic effect on B-lymphocytes. These results suggest that immunostimulating activity of Phillinus linteus might be associated with a funtional stimulation of B-lymphocyte involved in humoral immune responses.

Original language	English
Pages (from-to)	379-381
Number of pages	3
Journal	Archives of Pharmacal Research
Volume	15
Issue number	4
DOIs	https://doi.org/10.1007/BF02974118
State	Published - Dec 1992

Keywords

antibody-forming cell polyclonal antigen
Phellinus linteus
T-independent antigenic effect

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10.1007/BF02974118

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title = "Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte",

abstract = "Phellinus linteus was examined on its immunostimulating activities using an in vitro immunization and plaque forming cell assay. When lymphocytes were exposed to the extract of Phellinus linteus, the number of antibody forming cell was increased. In in vitro plaque forming cell assay, the immunostimulating effect was about 4.8 and 5.0 times of unimmunized control in polyclonal and T-independent antibody response, respectively. Especially, Phellinus linteus significantly increased the antigenicity of TNP-LPS used as T-independent antigen. But Phellinus linteus did not show a mitogenic effect on B-lymphocytes. These results suggest that immunostimulating activity of Phillinus linteus might be associated with a funtional stimulation of B-lymphocyte involved in humoral immune responses.",

keywords = "antibody-forming cell polyclonal antigen, Phellinus linteus, T-independent antigenic effect",

author = "Oh, {Goo Taeg} and Han, {Sang Bae} and Kim, {Hwan Mook} and Han, {Man Woo} and Yoo, {Ick Dong}",

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T1 - Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte

AU - Oh, Goo Taeg

AU - Han, Sang Bae

AU - Kim, Hwan Mook

AU - Han, Man Woo

AU - Yoo, Ick Dong

PY - 1992/12

Y1 - 1992/12

N2 - Phellinus linteus was examined on its immunostimulating activities using an in vitro immunization and plaque forming cell assay. When lymphocytes were exposed to the extract of Phellinus linteus, the number of antibody forming cell was increased. In in vitro plaque forming cell assay, the immunostimulating effect was about 4.8 and 5.0 times of unimmunized control in polyclonal and T-independent antibody response, respectively. Especially, Phellinus linteus significantly increased the antigenicity of TNP-LPS used as T-independent antigen. But Phellinus linteus did not show a mitogenic effect on B-lymphocytes. These results suggest that immunostimulating activity of Phillinus linteus might be associated with a funtional stimulation of B-lymphocyte involved in humoral immune responses.

AB - Phellinus linteus was examined on its immunostimulating activities using an in vitro immunization and plaque forming cell assay. When lymphocytes were exposed to the extract of Phellinus linteus, the number of antibody forming cell was increased. In in vitro plaque forming cell assay, the immunostimulating effect was about 4.8 and 5.0 times of unimmunized control in polyclonal and T-independent antibody response, respectively. Especially, Phellinus linteus significantly increased the antigenicity of TNP-LPS used as T-independent antigen. But Phellinus linteus did not show a mitogenic effect on B-lymphocytes. These results suggest that immunostimulating activity of Phillinus linteus might be associated with a funtional stimulation of B-lymphocyte involved in humoral immune responses.

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Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte

Abstract

Keywords

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