Immunoreactivity of CD99 in non-Hodgkin's lymphoma: Unexpected frequent expression in ALK-positive anaplastic large cell lymphoma

Ohk Sung Chang, Young H. Ko, Sanghui Park, Kihyun Kim, Wonseog Kim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

To verify the spectrum of CD99-expressing lymphoid malignancy, an immunohistochemical study for CD99 was carried out in 182 cases of non-Hodgkin's lymphoma, including 21 lymphoblastic lymphomas, 11 small lymphocytic lymphomas, 9 mantle cell lymphomas, 12 follicular lymphomas, 37 diffuse large B cell lymphomas, 18 Burkitt's lymphomas, 28 NK/T-cell lymphomas, 8 angioimmunoblastic T-cell lymphomas, 23 peripheral T-cell lymphomas, unspecified, and 15 systemic anaplastic large cell lymphomas. CD99 was positive in all T-lymphoblastic lymphomas and in 60% of B-lymphoblastic lymphomas. Majority of T and NK cell lymphomas were negative for CD99, except anaplastic large cell lymphomas (ALCLs). Eight of 15 cases (54%) of ALCLs reacted with anti CD99 antibody. Seven of 10 (70%) ALK positive ALCLs expressed CD99, whereas only 1 of 5 (20%) ALK negative ALCLs were positive. Of the mature B-cell lymphomas, 5.4% (2/37) of diffuse large B cell lymphomas and 11.1% (2/18) of Burkitt's lymphomas expressed CD99. In conclusion, CD99 is infrequently expressed in mature B and T cell lymphomas, except ALK-positive ALCL. High expression of CD99 in ALK-positive ALCL is unexpected finding and its biologic and clinical significances have yet to be clarified.

Original languageEnglish
Pages (from-to)952-956
Number of pages5
JournalJournal of Korean Medical Science
Volume20
Issue number6
DOIs
StatePublished - Dec 2005

Keywords

  • CD99 protein, human
  • Lymphoma, Large-Cell, Ki-1
  • Lymphoma, Non-Hodgkin

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