TY - JOUR
T1 - Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients
T2 - A Cross-Sectional Study in Korea
AU - Song, Seung Hwan
AU - Chung, Ku Yong
AU - Jee, Yongho
AU - Chung, Hae Sun
AU - Kim, Kina
AU - Minn, Dohsik
AU - Kim, Soo Kyung
N1 - Publisher Copyright:
© 2023 The Korean Academy of Medical Sciences
PY - 2023
Y1 - 2023
N2 - Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (≥ 100 U/mL) and neutralizing antibody responses (≥ 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1–2.4, 2.5–4.9, and ≥ 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7–52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine.
AB - Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (≥ 100 U/mL) and neutralizing antibody responses (≥ 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1–2.4, 2.5–4.9, and ≥ 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7–52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine.
KW - COVID-19
KW - Kidney Transplantation
KW - SARS-CoV-2
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85147461206&partnerID=8YFLogxK
U2 - 10.3346/jkms.2023.38.e22
DO - 10.3346/jkms.2023.38.e22
M3 - Article
C2 - 36747360
AN - SCOPUS:85147461206
SN - 1011-8934
VL - 38
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 5
M1 - e22
ER -