Immunogenicity of menACWY-CRM in Korean military recruits: Influence of tetanus-diphtheria toxoid vaccination on the vaccine response to menACWY-CRM

Han Wool Kim, In Ho Park, Sooseong You, Hee Tae Yu, In Soo Oh, Pil Soo Sung, Eui Cheol Shin, Kyung Hyo Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.

Original languageEnglish
Pages (from-to)1511-1516
Number of pages6
JournalYonsei Medical Journal
Volume57
Issue number6
DOIs
StatePublished - Nov 2016

Keywords

  • Meningococcal vaccine
  • Neisseria meningitidis
  • Serum bactericidal antibody assay

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