TY - JOUR
T1 - Immunogenicity of menACWY-CRM in Korean military recruits
T2 - Influence of tetanus-diphtheria toxoid vaccination on the vaccine response to menACWY-CRM
AU - Kim, Han Wool
AU - Park, In Ho
AU - You, Sooseong
AU - Yu, Hee Tae
AU - Oh, In Soo
AU - Sung, Pil Soo
AU - Shin, Eui Cheol
AU - Kim, Kyung Hyo
N1 - Publisher Copyright:
© Yonsei University College of Medicine 2016.
PY - 2016/11
Y1 - 2016/11
N2 - The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
AB - The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
KW - Meningococcal vaccine
KW - Neisseria meningitidis
KW - Serum bactericidal antibody assay
UR - http://www.scopus.com/inward/record.url?scp=84986917897&partnerID=8YFLogxK
U2 - 10.3349/ymj.2016.57.6.1511
DO - 10.3349/ymj.2016.57.6.1511
M3 - Article
C2 - 27593883
AN - SCOPUS:84986917897
SN - 0513-5796
VL - 57
SP - 1511
EP - 1516
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
IS - 6
ER -