Immunogenicity and safety of two different Haemophilus influenzae type b conjugate vaccines in Korean infants

Kyung Hyo Kim, Hyunju Lee, Eun Hee Chung, Jin Han Kang, Jong Hyun Kim, Jung Soo Kim, Hoan Jong Lee, Sung Hee Oh, Eun Ae Park, Su Eun Park

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The incidence of invasive diseases, including meningitis caused by Haemophilus influenzae type b (Hib) was markedly decreased after routine immunization of Hib vaccine through diverse schedules in many countries. The purpose of this study was to evaluate the immunogenicity and safety of Hib conjugate vaccines in Korean children before the implementation of a national immunization program against Hib in Korea. A multicenter controlled trial was performed on two different Hib vaccines in Korean children. A total of 319 infants were enrolled: 199 infants were immunized with the Hib polysaccharide conjugated to the tetanus toxoid (PRP-T) and 120 infants with the Hib polysaccharide conjugated to the outer-membrane protein of Neisseria meningitides (PRP-OMP). Immunogenicity was evaluated by enzyme-linked immunosorbent assay (ELISA) and serum bactericidal assay. Both vaccines showed good immunologic responses after primary immunization. After 2 doses of PRP-T or PRP-OMP, 78.9% and 91.7% of infants achieved an antibody level of ≥1.0 μg/mL, respectively. Both vaccines were safe and well-tolerated. No serious adverse events were observed. Thus, Hib conjugate vaccines appear to be safe and show good immunogenicity in Korean infants. These results will be important reference data for the implementation of Hib vaccine in the national immunization program of Korea.

Original languageEnglish
Pages (from-to)929-936
Number of pages8
JournalJournal of Korean Medical Science
Issue number6
StatePublished - Dec 2008


  • Haemophilus
  • Immunogenicity
  • Safety
  • Vaccines


Dive into the research topics of 'Immunogenicity and safety of two different Haemophilus influenzae type b conjugate vaccines in Korean infants'. Together they form a unique fingerprint.

Cite this