Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

Thanh Chung Pham; Dong Joon Lee; Do Hun Kim; Juyoung Yoon; Tran Dai Lam; Hwan Myung Kim; Songyi Lee

doi:10.1039/d3cc00108c

Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

Thanh Chung Pham
, Dong Joon Lee
, Do Hun Kim
, Juyoung Yoon
, Tran Dai Lam
, Hwan Myung Kim
, Songyi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

Original language	English
Pages (from-to)	4503-4506
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	30
DOIs	https://doi.org/10.1039/d3cc00108c
State	Published - 20 Mar 2023

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© 2023 The Royal Society of Chemistry.

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10.1039/d3cc00108c

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abstract = "A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.",

author = "Pham, \{Thanh Chung\} and Lee, \{Dong Joon\} and Kim, \{Do Hun\} and Juyoung Yoon and Lam, \{Tran Dai\} and Kim, \{Hwan Myung\} and Songyi Lee",

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T1 - Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

AU - Pham, Thanh Chung

AU - Lee, Dong Joon

AU - Kim, Do Hun

AU - Yoon, Juyoung

AU - Lam, Tran Dai

AU - Kim, Hwan Myung

AU - Lee, Songyi

PY - 2023/3/20

Y1 - 2023/3/20

N2 - A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

AB - A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

UR - https://www.scopus.com/pages/publications/85151826209

U2 - 10.1039/d3cc00108c

DO - 10.1039/d3cc00108c

M3 - Article

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AN - SCOPUS:85151826209

SN - 1359-7345

VL - 59

SP - 4503

EP - 4506

JO - Chemical Communications

JF - Chemical Communications

IS - 30

ER -

Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

Abstract

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