Abstract
Singlet oxygen is a cytotoxic reactive species which is involved in the photodynamic therapy of cancer. It is also known to be produced endogenously in most eukaryotic cells and implicated in many biochemical processes, including apoptotic response. We now report that Bodipy based fluorescent dyes with singlet oxygen reactive modules, signal the intracellular generation of singlet oxygen through photosensitization. We believe long wavelength probes of singlet oxygen, based on this approach will be highly valuable.
Original language | English |
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Article number | 109158 |
Journal | Dyes and Pigments |
Volume | 188 |
DOIs | |
State | Published - Apr 2021 |
Bibliographical note
Funding Information:We thank LiaoNing (China) Revitalization Talents Program XLYC 1902001 (E.U.A) and National Research Foundation ( NRF ) funded by Korean government ( MSIP ) ( 2012R1A3A2048814 ) (J.Y.) for their generous support.
Publisher Copyright:
© 2021 Elsevier Ltd
Keywords
- Bodipy
- Fluorescent probe
- Photodynamic therapy
- Reactive oxygen species
- Singlet oxygen probe