Imaging of intracellular singlet oxygen with bright BODIPY dyes

Serdal Kaya, Yahya A. Ismaiel, Nahyun Kwon, Gyoungmi Kim, Jose L. Bila, Juyoung Yoon, Ozlem Seven, Engin U. Akkaya

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Singlet oxygen is a cytotoxic reactive species which is involved in the photodynamic therapy of cancer. It is also known to be produced endogenously in most eukaryotic cells and implicated in many biochemical processes, including apoptotic response. We now report that Bodipy based fluorescent dyes with singlet oxygen reactive modules, signal the intracellular generation of singlet oxygen through photosensitization. We believe long wavelength probes of singlet oxygen, based on this approach will be highly valuable.

Original languageEnglish
Article number109158
JournalDyes and Pigments
StatePublished - Apr 2021

Bibliographical note

Funding Information:
We thank LiaoNing (China) Revitalization Talents Program XLYC 1902001 (E.U.A) and National Research Foundation ( NRF ) funded by Korean government ( MSIP ) ( 2012R1A3A2048814 ) (J.Y.) for their generous support.

Publisher Copyright:
© 2021 Elsevier Ltd


  • Bodipy
  • Fluorescent probe
  • Photodynamic therapy
  • Reactive oxygen species
  • Singlet oxygen probe


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