Identification of Staphylococcus xylosus isolated from C57BL/6J-Nos2tm1Lau mice with dermatitis

Young Suk Won, Hyo Jung Kwon, Goo Taeg Oh, Bang Hyun Kim, Chul Ho Lee, Yong Ho Park, Byung Hwa Hyun, Yang Kyu Choi

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33 Scopus citations


Coagulase negative staphylococci (CNS) are significant pathogens, particularly in medical device related infections and in immunocompromised patients. Five CNS strains were isolated from 5 NOS2 knock-out mice with dermatitis. Histologically, granulomatous dermatitis was found in the skin around the ear with epidermal ulceration. Dermal lesions included pustules, necrosis, and accumulations of neutrophils and macrophages. Isolates of the bacterial strains were identified to be Staphylococcus xylosus by the API STAPH kit and 16S-23S intergenic transcribed spacer-PCR. These results demonstrate the potential of this organism to be an opportunistic pathogen in immunocompromised mice.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalMicrobiology and Immunology
Issue number9
StatePublished - 2002


  • Granulomatous dermatitis
  • Staphylococcus xylosus


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