Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells

Saeyoung Park; Mina Lee; Hosoon Lee; Hae Yeong Kim; Yun Sil Lee; Shinwu Jeong; Doo Il Jeoung

doi:10.1023/A:1020665820180

Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells

Saeyoung Park, Mina Lee, Hosoon Lee, Hae Yeong Kim, Yun Sil Lee, Shinwu Jeong, Doo Il Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.

Original language	English
Pages (from-to)	1651-1657
Number of pages	7
Journal	Biotechnology Letters
Volume	24
Issue number	20
DOIs	https://doi.org/10.1023/A:1020665820180
State	Published - Oct 2002

Keywords

5-fluorouracil
CDNA microarray
Gastric cancer cells
Signature genes

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title = "Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells",

abstract = "A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.",

keywords = "5-fluorouracil, CDNA microarray, Gastric cancer cells, Signature genes",

author = "Saeyoung Park and Mina Lee and Hosoon Lee and Kim, {Hae Yeong} and Lee, {Yun Sil} and Shinwu Jeong and Jeoung, {Doo Il}",

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AU - Lee, Hosoon

AU - Kim, Hae Yeong

AU - Lee, Yun Sil

AU - Jeong, Shinwu

AU - Jeoung, Doo Il

PY - 2002/10

Y1 - 2002/10

N2 - A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.

AB - A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.

KW - 5-fluorouracil

KW - CDNA microarray

KW - Gastric cancer cells

KW - Signature genes

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DO - 10.1023/A:1020665820180

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Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells

Abstract

Keywords

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