Identification of Nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV)

Green Bae, Jae Rang Yu, Jun Lee, Jun Chang, Eun Kyoung Seo

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29 Scopus citations

Abstract

Three known phenolic compounds, (-)-(R)-nyasol (=4,4′-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3) - isolated from the rhizomes of Anemarrhena asphodeloides - were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 = 1.15 μm). In addition, the known, but inactive, compound 'trans-N-(para-coumaroyl)tyramine' (=(2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; 4) was isolated from this plant for the first time.

Original languageEnglish
Pages (from-to)2231-2235
Number of pages5
JournalChemistry and Biodiversity
Volume4
Issue number9
DOIs
StatePublished - 2007

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