Identification of new pyrrole alkaloids from the fruits of Lycium chinense

Ui Joung Youn, Joo Yun Lee, Yun Seo Kil, Ah Reum Han, Chong Hak Chae, Shi Yong Ryu, Eun Kyoung Seo

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16 Scopus citations


Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1-4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2-4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalArchives of Pharmacal Research
Issue number3
StatePublished - Mar 2016

Bibliographical note

Funding Information:
This paper (Youn UJ) was supported by [RP-Grant 2010 of Ewha Womans University].

Publisher Copyright:
© The Pharmaceutical Society of Korea 2015.


  • Absolute configuration
  • ECD
  • Lycium chinense
  • Pyrrole alkaloid
  • Solanaceae


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