Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Seongeun Lee; Myungin Baek; Hankwang Yang; Yung Jue Bang; Woo Ho Kim; Ji Hong Ha; Dae Kee Kim; Doo Il Jeoung

doi:10.1016/S0304-3835(02)00197-0

Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Seongeun Lee, Myungin Baek, Hankwang Yang, Yung Jue Bang, Woo Ho Kim, Ji Hong Ha, Dae Kee Kim, Doo Il Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.

Original language	English
Pages (from-to)	197-206
Number of pages	10
Journal	Cancer Letters
Volume	184
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(02)00197-0
State	Published - 28 Oct 2002

Keywords

Gastric cancer
Lauren
Metastasis
cDNA microarray

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title = "Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays",

abstract = "To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.",

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author = "Seongeun Lee and Myungin Baek and Hankwang Yang and Bang, {Yung Jue} and Kim, {Woo Ho} and Ha, {Ji Hong} and Kim, {Dae Kee} and Jeoung, {Doo Il}",

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T1 - Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

AU - Lee, Seongeun

AU - Baek, Myungin

AU - Yang, Hankwang

AU - Bang, Yung Jue

AU - Kim, Woo Ho

AU - Ha, Ji Hong

AU - Kim, Dae Kee

AU - Jeoung, Doo Il

PY - 2002/10/28

Y1 - 2002/10/28

N2 - To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.

AB - To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.

KW - Gastric cancer

KW - Lauren

KW - Metastasis

KW - cDNA microarray

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SN - 0304-3835

VL - 184

SP - 197

EP - 206

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Abstract

Keywords

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