Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Seongeun Lee, Myungin Baek, Hankwang Yang, Yung Jue Bang, Woo Ho Kim, Ji Hong Ha, Dae Kee Kim, Doo Il Jeoung

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalCancer Letters
Volume184
Issue number2
DOIs
StatePublished - 28 Oct 2002

Keywords

  • Gastric cancer
  • Lauren
  • Metastasis
  • cDNA microarray

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