Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui; Seul Lee Ye; Jeong Hana; Lee Jun; Joo Won Nam; Jin Lee Yoo; Sook Hwang Eun; Je Hyun Lee; Lee Dongho; Sik Kang Sam; Eun Kyoung Seo

doi:10.1021/np900397f

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui
, Seul Lee Ye
, Jeong Hana
, Lee Jun
, Joo Won Nam
, Jin Lee Yoo
, Sook Hwang Eun
, Je Hyun Lee
, Lee Dongho
, Sik Kang Sam
, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC₅₀ value of 5.3 μM.

Original language	English
Pages (from-to)	1895-1898
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/np900397f
State	Published - 23 Oct 2009

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title = "Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides",

abstract = "Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.",

author = "Ui, \{Joung Youn\} and Ye, \{Seul Lee\} and Jeong Hana and Lee Jun and Nam, \{Joo Won\} and Yoo, \{Jin Lee\} and Eun, \{Sook Hwang\} and Lee, \{Je Hyun\} and Lee Dongho and Sam, \{Sik Kang\} and Seo, \{Eun Kyoung\}",

year = "2009",

month = oct,

day = "23",

doi = "10.1021/np900397f",

language = "English",

volume = "72",

pages = "1895--1898",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

AU - Ui, Joung Youn

AU - Ye, Seul Lee

AU - Hana, Jeong

AU - Jun, Lee

AU - Nam, Joo Won

AU - Yoo, Jin Lee

AU - Eun, Sook Hwang

AU - Lee, Je Hyun

AU - Dongho, Lee

AU - Sam, Sik Kang

AU - Seo, Eun Kyoung

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

AB - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

UR - https://www.scopus.com/pages/publications/70350475514

U2 - 10.1021/np900397f

DO - 10.1021/np900397f

M3 - Article

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AN - SCOPUS:70350475514

SN - 0163-3864

VL - 72

SP - 1895

EP - 1898

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Abstract

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