Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui; Seul Lee Ye; Jeong Hana; Lee Jun; Joo Won Nam; Jin Lee Yoo; Sook Hwang Eun; Je Hyun Lee; Lee Dongho; Sik Kang Sam; Eun Kyoung Seo

doi:10.1021/np900397f

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui, Seul Lee Ye, Jeong Hana, Lee Jun, Joo Won Nam, Jin Lee Yoo, Sook Hwang Eun, Je Hyun Lee, Lee Dongho, Sik Kang Sam, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC₅₀ value of 5.3 μM.

Original language	English
Pages (from-to)	1895-1898
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/np900397f
State	Published - 23 Oct 2009

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title = "Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides",

abstract = "Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.",

author = "Ui, \{Joung Youn\} and Ye, \{Seul Lee\} and Jeong Hana and Lee Jun and Nam, \{Joo Won\} and Yoo, \{Jin Lee\} and Eun, \{Sook Hwang\} and Lee, \{Je Hyun\} and Lee Dongho and Sam, \{Sik Kang\} and Seo, \{Eun Kyoung\}",

year = "2009",

month = oct,

day = "23",

doi = "10.1021/np900397f",

language = "English",

volume = "72",

pages = "1895--1898",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

AU - Ui, Joung Youn

AU - Ye, Seul Lee

AU - Hana, Jeong

AU - Jun, Lee

AU - Nam, Joo Won

AU - Yoo, Jin Lee

AU - Eun, Sook Hwang

AU - Lee, Je Hyun

AU - Dongho, Lee

AU - Sam, Sik Kang

AU - Seo, Eun Kyoung

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

AB - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

UR - https://www.scopus.com/pages/publications/70350475514

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DO - 10.1021/np900397f

M3 - Article

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AN - SCOPUS:70350475514

SN - 0163-3864

VL - 72

SP - 1895

EP - 1898

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

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