Identification of a new cytotoxic biflavanone from Selaginella doederleinii

Na Youn Lee; Hye Young Min; Jun Lee; Joo Won Nam; Yoo Jin Lee; Ah Reum Han; Adam Wiryawan; Wahyu Suprapto; Sang Kook Lee; Eun Kyoung Sec

doi:10.1248/cpb.56.1360

Identification of a new cytotoxic biflavanone from Selaginella doederleinii

Na Youn Lee
, Hye Young Min
, Jun Lee
, Joo Won Nam
, Yoo Jin Lee
, Ah Reum Han
, Adam Wiryawan
, Wahyu Suprapto
, Sang Kook Lee
, Eun Kyoung Sec

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A new biflavanone, 2,2″,3,3″-tetrahydrorobustaflavone 7,4′,7″ trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4′,7″ trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D-and 2D NMR experiments.

Original language	English
Pages (from-to)	1360-1361
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	9
DOIs	https://doi.org/10.1248/cpb.56.1360
State	Published - Sep 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biflavanone
Cytotoxicity
Selaginella doederleinii
Selaginellaceae

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10.1248/cpb.56.1360

Cite this

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title = "Identification of a new cytotoxic biflavanone from Selaginella doederleinii",

abstract = "A new biflavanone, 2,2″,3,3″-tetrahydrorobustaflavone 7,4′,7″ trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4′,7″ trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D-and 2D NMR experiments.",

keywords = "Biflavanone, Cytotoxicity, Selaginella doederleinii, Selaginellaceae",

author = "Lee, \{Na Youn\} and Min, \{Hye Young\} and Jun Lee and Nam, \{Joo Won\} and Lee, \{Yoo Jin\} and Han, \{Ah Reum\} and Adam Wiryawan and Wahyu Suprapto and Lee, \{Sang Kook\} and Sec, \{Eun Kyoung\}",

year = "2008",

month = sep,

doi = "10.1248/cpb.56.1360",

language = "English",

volume = "56",

pages = "1360--1361",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Identification of a new cytotoxic biflavanone from Selaginella doederleinii

AU - Lee, Na Youn

AU - Min, Hye Young

AU - Lee, Jun

AU - Nam, Joo Won

AU - Lee, Yoo Jin

AU - Han, Ah Reum

AU - Wiryawan, Adam

AU - Suprapto, Wahyu

AU - Lee, Sang Kook

AU - Sec, Eun Kyoung

PY - 2008/9

Y1 - 2008/9

N2 - A new biflavanone, 2,2″,3,3″-tetrahydrorobustaflavone 7,4′,7″ trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4′,7″ trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D-and 2D NMR experiments.

AB - A new biflavanone, 2,2″,3,3″-tetrahydrorobustaflavone 7,4′,7″ trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4′,7″ trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D-and 2D NMR experiments.

KW - Biflavanone

KW - Cytotoxicity

KW - Selaginella doederleinii

KW - Selaginellaceae

UR - https://www.scopus.com/pages/publications/51349143650

U2 - 10.1248/cpb.56.1360

DO - 10.1248/cpb.56.1360

M3 - Article

C2 - 18758121

AN - SCOPUS:51349143650

SN - 0009-2363

VL - 56

SP - 1360

EP - 1361

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 9

ER -

Identification of a new cytotoxic biflavanone from Selaginella doederleinii

Abstract

UN SDGs

Keywords

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