Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis

Pharmacology, Toxicology and Pharmaceutical Science

• Lung Fibrosis 100%
• Janus Kinase 1 100%
• Fibrosis 40%
• Mouse Model 20%
• Carboxylate 20%
• Bleomycin 20%
• Phosphotransferase 20%
• Side Effect 20%
• Disease 20%
• IC50 20%
• Inflammation 20%
• Bioavailability 20%
• Carboxamide 20%
• Janus Kinase 20%
• Pharmacokinetics 20%

Biochemistry, Genetics and Molecular Biology

• Janus Kinase 1 100%
• Mouse Model 20%
• IC50 20%
• Body Weight 20%
• STAT3 20%
• JAK-STAT Signaling Pathway 20%
• Kinase 20%
• Phosphotransferase 20%
• Pharmacokinetics 20%
• Janus Kinase 20%
• Bleomycin 20%