Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression

E. M. Park, B. P. Cho, B. T. Volpe, M. O. Cruz, T. H. Joh, S. Cho

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The inflammatory response accompanies and exacerbates the developing injury after cerebral ischemia. Ibuprofen, a non-steroidal anti-inflammatory drug, has been shown to attenuate injuries in animal models of various neurological diseases. In the present study, we investigated ibuprofen's neuroprotective effects in rats exposed to transient forebrain ischemia and in cultures exposed to oxygen glucose deprivation (OGD). Rats treated with ibuprofen after transient forebrain ischemia displayed long-lasting protection of CA1 hippocampal neurons. There were selective increases in interleukin-1 receptor antagonist gene and protein expression in ibuprofen-treated OGD microglia. Furthermore, treatment with ibuprofen in neuron/microglia co-cultures increased the number of surviving HC2S2 neurons against OGD whereas IL-1ra neutralizing antibody reversed the ibuprofen-induced neuroprotection. The data indicate that ibuprofen-induced IL-1ra secretion is involved in neuroprotection against ischemic conditions.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
Issue number3
StatePublished - 2005

Bibliographical note

Funding Information:
Supported by AHA grant 0030225N (S.C.) and Burke Foundation.


  • BV2 microglia
  • CA1 hippocampus
  • Global ischemia
  • Neuroprotection
  • Oxygen-glucose deprivation
  • Rat


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