Hypoxanthine levels in human urine serve as a screening indicator for the plasma total cholesterol and low-density lipoprotein modulation activities of fermented red pepper paste

Yujin Kim, Youn Je Park, Seung Ok Yang, So Hyun Kim, Sun Hee Hyun, Sayeon Cho, Young Suk Kim, Dae Young Kwon, Youn Soo Cha, Soowan Chae, Hyung Kyoon Choi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Fermented red pepper paste (FRPP) is one of the most well-known traditional foods in Korea. The effects of FRPP in experimental animals and adipocytes have been previously reported. However, the biochemical effects have not yet been validated in humans with various genetic backgrounds and environmental factors. In this study, 28 female volunteers (body mass index, more than 23 kg/m2) aged 19 to 60 years were treated with either FRPP or a placebo for 12 weeks. Marked cholesterol modulation was observed in the FRPP-treated group compared with the placebo group. Although the baseline (pretreatment) total cholesterol and low-density lipoprotein levels and body mass index of the volunteers did not differ significantly between the placebo- and FRPP-treated groups, FRPP caused a modulation of cholesterol levels not seen in the placebo group, causing either no variation or a decrease in low-density lipoprotein and total cholesterol levels. Thus, urinary metabolomic profiling of pretreatment samples was carried out in these 2 FRPP-treated groups using 1H-nuclear magnetic resonance-based metabolomic techniques. These 2 groups, with their opposing cholesterol-modulation tendencies, could be clearly differentiated by orthogonal projections to latent structures-discriminant analysis-derived score plots. In addition, their levels of hypoxanthine differed markedly. We propose that urinary hypoxanthine levels can be used as a screening biomarker to predict the efficacy of the cholesterol-modulating activity of FRPP in human subjects.

Original languageEnglish
Pages (from-to)455-461
Number of pages7
JournalNutrition Research
Volume30
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Capsicum annuum
  • Cholesterol-modulation activity
  • Fermented red pepper paste
  • H-NMR
  • Metabolomics
  • Women

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