Hypolipidemia in patients with amyotrophic lateral sclerosis: A possible gender difference?

Ji Won Yang, Sung Min Kim, Hee Juang Kim, Jee Eun Kim, Kyung Seok Park, Seung Hyun Kim, Kwang Woo Lee, Jung Joon Sung

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background and Purpose We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls. Methods The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], protein, and glucose of 95 patients with ALS (60 men) were compared with those of 99 age-and sex-matched healthy controls (64 men). Both groups had normal dietary intakes. Results Total cholesterol (p=0.004), LDL (p=0.040), triglyceride (p=0.025), and protein (p=0.010) levels, and LDL/HDL ratios (p<0.001) in men with ALS were significantly lower than those in their control counterparts. There were no such significant differences in these parameters between female patients with ALS and female controls. Conclusions The serum levels of lipid and protein were significantly lower in male patients with ALS than in the male controls. Since we controlled for the confounding effects of dietary intake, hypolipidemia in ALS might be associated with the pathophysiology of the disease rather than being the result of the decreased dietary intake in ALS patients. Metabolic demand might increase in ALS, and it may be affected by gender.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Clinical Neurology (Korea)
Issue number2
StatePublished - Apr 2013


  • Amyotrophic lateral sclerosis
  • Dyslipidemia
  • Gender differences


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