Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome

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Abstract

Objective To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities. Design Cross-sectional case-control study. Setting Academic medical setting. Patient(s) A total of 1,062 women with PCOS and 1,887 women without PCOS. Intervention(s) None. Main Outcome Measure(s) Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels. Result(s) A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis. Conclusion(s) A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.

Original languageEnglish
Pages (from-to)840-845
Number of pages6
JournalFertility and Sterility
Volume101
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Hyperandrogenemia
  • metabolic morbidity
  • polycystic ovary syndrome
  • reproductive morbidity

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