Hydrogen peroxide induces hyphal differentiation in Candida albicans

Olviyani Nasution; Kavitha Srinivasa; Minsun Kim; Yeo Jung Kim; Wankee Kim; Woojin Jeong; Wonja Choi

doi:10.1128/EC.00105-08

Hydrogen peroxide induces hyphal differentiation in Candida albicans

Olviyani Nasution, Kavitha Srinivasa, Minsun Kim, Yeo Jung Kim, Wankee Kim, Woojin Jeong, Wonja Choi

Department of Life Science

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Abstract

In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H₂O₂ in Candida albicans. This finding is confirmed by the changing intracellular concentration of H₂O₂. In order to induce the same level of differentiation, low concentrations of exogenous H₂O₂ are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.

Original language	English
Pages (from-to)	2008-2011
Number of pages	4
Journal	Eukaryotic Cell
Volume	7
Issue number	11
DOIs	https://doi.org/10.1128/EC.00105-08
State	Published - Nov 2008

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AU - Jeong, Woojin

AU - Choi, Wonja

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AB - In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H2O2 in Candida albicans. This finding is confirmed by the changing intracellular concentration of H2O2. In order to induce the same level of differentiation, low concentrations of exogenous H2O2 are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.

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Hydrogen peroxide induces hyphal differentiation in Candida albicans

Abstract

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