Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin; Jin Xie; Lei Zhu; Seulki Lee; Gang Niu; Ying Ma; Kwangmeyung Kim; Xiaoyuan Chen

doi:10.1002/anie.201006757

Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin, Jin Xie, Lei Zhu, Seulki Lee, Gang Niu, Ying Ma, Kwangmeyung Kim, Xiaoyuan Chen

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

Original language	English
Pages (from-to)	1569-1572
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	7
DOIs	https://doi.org/10.1002/anie.201006757
State	Published - 11 Feb 2011

Keywords

ferritin
fluorescent probes
imaging agents
metalloenzymes
nanoparticles

Access to Document

10.1002/anie.201006757

Cite this

@article{e936111f111049c2bd5c6c9867590b6c,

title = "Hybrid ferritin nanoparticles as activatable probes for tumor imaging",

abstract = "Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.",

keywords = "ferritin, fluorescent probes, imaging agents, metalloenzymes, nanoparticles",

author = "Xin Lin and Jin Xie and Lei Zhu and Seulki Lee and Gang Niu and Ying Ma and Kwangmeyung Kim and Xiaoyuan Chen",

year = "2011",

month = feb,

day = "11",

doi = "10.1002/anie.201006757",

language = "English",

volume = "50",

pages = "1569--1572",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Hybrid ferritin nanoparticles as activatable probes for tumor imaging

AU - Lin, Xin

AU - Xie, Jin

AU - Zhu, Lei

AU - Lee, Seulki

AU - Niu, Gang

AU - Ma, Ying

AU - Kim, Kwangmeyung

AU - Chen, Xiaoyuan

PY - 2011/2/11

Y1 - 2011/2/11

N2 - Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

AB - Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

KW - ferritin

KW - fluorescent probes

KW - imaging agents

KW - metalloenzymes

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/79851476422

U2 - 10.1002/anie.201006757

DO - 10.1002/anie.201006757

M3 - Article

C2 - 21308906

AN - SCOPUS:79851476422

SN - 1433-7851

VL - 50

SP - 1569

EP - 1572

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 7

ER -

Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Abstract

Keywords

Access to Document

Fingerprint

Cite this