Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 11 Feb 2011|
- fluorescent probes
- imaging agents