Abstract
Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.
Original language | English |
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Pages (from-to) | 1569-1572 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 7 |
DOIs | |
State | Published - 11 Feb 2011 |
Keywords
- ferritin
- fluorescent probes
- imaging agents
- metalloenzymes
- nanoparticles