Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin, Jin Xie, Lei Zhu, Seulki Lee, Gang Niu, Ying Ma, Kwangmeyung Kim, Xiaoyuan Chen

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

Original languageEnglish
Pages (from-to)1569-1572
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number7
DOIs
StatePublished - 11 Feb 2011

Keywords

  • ferritin
  • fluorescent probes
  • imaging agents
  • metalloenzymes
  • nanoparticles

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