Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery

Ju Hwan Park, Hyun Jong Cho, Hong Yeol Yoon, In Soo Yoon, Seung Hak Ko, Jae Seong Shim, Jee Hyun Cho, Jae Hyung Park, Kwangmeyung Kim, Ick Chan Kwon, Dae Duk Kim

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198 Scopus citations


Nanohybrid liposomes coated with amphiphilic hyaluronic acid-ceramide (HACE) was fabricated for targeted delivery of anticancer drug and in vivo cancer imaging. Nanohybrid liposomes including doxorubicin (DOX) and Magnevist, a contrast agent for magnetic resonance (MR) imaging, with 120-130 nm mean diameter and a narrow size distribution were developed. DOX release from the developed formulation was improved at acidic pH (pH 5.5 and 6.8) versus physiological pH (pH 7.4). Cytotoxicity induced by the blank plain liposome was reduced by coating the outer surface of the nanohybrid liposome with HACE. Cellular uptake of DOX from the nanohybrid liposome was enhanced by HA and CD44 receptor interaction, versus the plain liposome. In vivo contrast-enhancing effects revealed that the nanohybrid liposome can be used as a tumor targeting MR imaging probe for cancer diagnosis. In a pharmacokinetic study in rats, in vivo clearance of DOX was decreased in the order DOX solution, plain liposome (F2), and nanohybrid liposome (F3), indicating prolonged circulation of the drug in the blood stream and improved therapeutic efficacy of the nanohybrid liposome (F3). Based on these findings, the nanohybrid liposomal system may be a useful candidate for real-time cancer diagnosis and therapy.

Original languageEnglish
Pages (from-to)98-108
Number of pages11
JournalJournal of Controlled Release
Issue number1
StatePublished - 28 Jan 2014

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2009-0083533 and NRF- 2012R1A1A1038944 ).


  • Doxorubicin
  • Hyaluronic acid-ceramide
  • Hybrid nanostructure
  • Lipid
  • Magnetic resonance imaging


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