Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links

Yi Jun Kim; Hyun Guy Kang; Jin Hong Kim

doi:10.1016/j.xcrm.2023.101385

Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links

Yi Jun Kim, Hyun Guy Kang, Jin Hong Kim

Department of Environmental Medicine

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD⁺ dependencies for survival.¹ Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.

Original language	English
Article number	101385
Journal	Cell Reports Medicine
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.xcrm.2023.101385
State	Published - 16 Jan 2024

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© 2023 The Author(s)

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title = "Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links",

abstract = "In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD+ dependencies for survival.1 Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.",

author = "Kim, \{Yi Jun\} and Kang, \{Hyun Guy\} and Kim, \{Jin Hong\}",

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AU - Kang, Hyun Guy

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N2 - In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD+ dependencies for survival.1 Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.

AB - In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD+ dependencies for survival.1 Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.

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DO - 10.1016/j.xcrm.2023.101385

M3 - Comment/debate

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SN - 2666-3791

VL - 5

JO - Cell Reports Medicine

JF - Cell Reports Medicine

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Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links

Abstract

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