Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Dae Sik Jang, Hye Young Min, Moon Sun Kim, Ah Reum Han, Tri Windono, Gwang Ho Jeohn, Sik Kang Sam, Sang Kook Lee, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E- humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC50 values of 14.1 and 23.5 μM, respectively, by bioassay-guided fractionation (positive control: Nω-monomethyl-L- arginine, IC50=21.3 μM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR.

Original languageEnglish
Pages (from-to)829-831
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • 5-hydroxyzerumbone
  • Nitric oxide production
  • Zerumboneoxide
  • Zingiber zerumbet

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