Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

Timothy B. Baker; Robert B. Weiss; Daniel Bolt; Andrew von Niederhausern; Michael C. Fiore; Diane M. Dunn; Megan E. Piper; Nori Matsunami; Stevens S. Smith; Hilary Coon; William M. McMahon; Mary B. Scholand; Nanda Singh; John R. Hoidal; Su Young Kim; Mark F. Leppert; Dale S. Cannon

doi:10.1093/ntr/ntp064

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

Timothy B. Baker, Robert B. Weiss, Daniel Bolt, Andrew von Niederhausern, Michael C. Fiore, Diane M. Dunn, Megan E. Piper, Nori Matsunami, Stevens S. Smith, Hilary Coon, William M. McMahon, Mary B. Scholand, Nanda Singh, John R. Hoidal, Su Young Kim, Mark F. Leppert, Dale S. Cannon

Department of Psychology

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Introduction: Previous research revealed significant associations between haplotypes in the CHRNA5-A3-B4 subunit cluster and scores on the Fagerström Test for Nicotine Dependence among individuals reporting daily smoking by age 17. The present study used subsamples of participants from that study to investigate associations between the CHRNA5-A3-B4 haplotypes and an array of phenotypes not analyzed previously (i.e., withdrawal severity, ability to stop smoking, and specific scales on the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) that reflect loss of control, strong craving, and heavy smoking. Methods: Two cohorts of current or former smokers (N = 886) provided both self-report data and DNA samples. One sample (Wisconsin) comprised smokers making a quit smoking attempt, which permitted the assessment of withdrawal and relapse during the attempt. The other sample (Utah) comprised participants studied for risk factors for nicotine dependence and chronic obstructive pulmonary disease and included individuals originally recruited in the Lung Health Study. Results: The CHRNA5-A3-B4 haplotypes were significantly associated with the targeted WISDM-68 scales (Tolerance, Craving, Loss of Control) in both samples of participants but only among individuals who began smoking early in life. The haplotypes were significantly associated with relapse likelihood and withdrawal severity, but these associations showed no evidence of an interaction with age at daily smoking. Discussion: The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking.

Original language	English
Pages (from-to)	785-796
Number of pages	12
Journal	Nicotine and Tobacco Research
Volume	11
Issue number	7
DOIs	https://doi.org/10.1093/ntr/ntp064
State	Published - 2009

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Baker, T. B., Weiss, R. B., Bolt, D., von Niederhausern, A., Fiore, M. C., Dunn, D. M., Piper, M. E., Matsunami, N., Smith, S. S., Coon, H., McMahon, W. M., Scholand, M. B., Singh, N., Hoidal, J. R., Kim, S. Y., Leppert, M. F., & Cannon, D. S. (2009). Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine and Tobacco Research, 11(7), 785-796. https://doi.org/10.1093/ntr/ntp064

@article{d837a4ef49794373b0a4079f9f477e38,

title = "Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes",

abstract = "Introduction: Previous research revealed significant associations between haplotypes in the CHRNA5-A3-B4 subunit cluster and scores on the Fagerstr{\"o}m Test for Nicotine Dependence among individuals reporting daily smoking by age 17. The present study used subsamples of participants from that study to investigate associations between the CHRNA5-A3-B4 haplotypes and an array of phenotypes not analyzed previously (i.e., withdrawal severity, ability to stop smoking, and specific scales on the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) that reflect loss of control, strong craving, and heavy smoking. Methods: Two cohorts of current or former smokers (N = 886) provided both self-report data and DNA samples. One sample (Wisconsin) comprised smokers making a quit smoking attempt, which permitted the assessment of withdrawal and relapse during the attempt. The other sample (Utah) comprised participants studied for risk factors for nicotine dependence and chronic obstructive pulmonary disease and included individuals originally recruited in the Lung Health Study. Results: The CHRNA5-A3-B4 haplotypes were significantly associated with the targeted WISDM-68 scales (Tolerance, Craving, Loss of Control) in both samples of participants but only among individuals who began smoking early in life. The haplotypes were significantly associated with relapse likelihood and withdrawal severity, but these associations showed no evidence of an interaction with age at daily smoking. Discussion: The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking.",

author = "Baker, {Timothy B.} and Weiss, {Robert B.} and Daniel Bolt and {von Niederhausern}, Andrew and Fiore, {Michael C.} and Dunn, {Diane M.} and Piper, {Megan E.} and Nori Matsunami and Smith, {Stevens S.} and Hilary Coon and McMahon, {William M.} and Scholand, {Mary B.} and Nanda Singh and Hoidal, {John R.} and Kim, {Su Young} and Leppert, {Mark F.} and Cannon, {Dale S.}",

year = "2009",

doi = "10.1093/ntr/ntp064",

language = "English",

volume = "11",

pages = "785--796",

journal = "Nicotine and Tobacco Research",

issn = "1462-2203",

publisher = "Oxford University Press",

number = "7",

}

Baker, TB, Weiss, RB, Bolt, D, von Niederhausern, A, Fiore, MC, Dunn, DM, Piper, ME, Matsunami, N, Smith, SS, Coon, H, McMahon, WM, Scholand, MB, Singh, N, Hoidal, JR, Kim, SY, Leppert, MF & Cannon, DS 2009, 'Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes', Nicotine and Tobacco Research, vol. 11, no. 7, pp. 785-796. https://doi.org/10.1093/ntr/ntp064

TY - JOUR

T1 - Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

AU - Baker, Timothy B.

AU - Weiss, Robert B.

AU - Bolt, Daniel

AU - von Niederhausern, Andrew

AU - Fiore, Michael C.

AU - Dunn, Diane M.

AU - Piper, Megan E.

AU - Matsunami, Nori

AU - Smith, Stevens S.

AU - Coon, Hilary

AU - McMahon, William M.

AU - Scholand, Mary B.

AU - Singh, Nanda

AU - Hoidal, John R.

AU - Kim, Su Young

AU - Leppert, Mark F.

AU - Cannon, Dale S.

PY - 2009

Y1 - 2009

N2 - Introduction: Previous research revealed significant associations between haplotypes in the CHRNA5-A3-B4 subunit cluster and scores on the Fagerström Test for Nicotine Dependence among individuals reporting daily smoking by age 17. The present study used subsamples of participants from that study to investigate associations between the CHRNA5-A3-B4 haplotypes and an array of phenotypes not analyzed previously (i.e., withdrawal severity, ability to stop smoking, and specific scales on the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) that reflect loss of control, strong craving, and heavy smoking. Methods: Two cohorts of current or former smokers (N = 886) provided both self-report data and DNA samples. One sample (Wisconsin) comprised smokers making a quit smoking attempt, which permitted the assessment of withdrawal and relapse during the attempt. The other sample (Utah) comprised participants studied for risk factors for nicotine dependence and chronic obstructive pulmonary disease and included individuals originally recruited in the Lung Health Study. Results: The CHRNA5-A3-B4 haplotypes were significantly associated with the targeted WISDM-68 scales (Tolerance, Craving, Loss of Control) in both samples of participants but only among individuals who began smoking early in life. The haplotypes were significantly associated with relapse likelihood and withdrawal severity, but these associations showed no evidence of an interaction with age at daily smoking. Discussion: The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking.

AB - Introduction: Previous research revealed significant associations between haplotypes in the CHRNA5-A3-B4 subunit cluster and scores on the Fagerström Test for Nicotine Dependence among individuals reporting daily smoking by age 17. The present study used subsamples of participants from that study to investigate associations between the CHRNA5-A3-B4 haplotypes and an array of phenotypes not analyzed previously (i.e., withdrawal severity, ability to stop smoking, and specific scales on the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) that reflect loss of control, strong craving, and heavy smoking. Methods: Two cohorts of current or former smokers (N = 886) provided both self-report data and DNA samples. One sample (Wisconsin) comprised smokers making a quit smoking attempt, which permitted the assessment of withdrawal and relapse during the attempt. The other sample (Utah) comprised participants studied for risk factors for nicotine dependence and chronic obstructive pulmonary disease and included individuals originally recruited in the Lung Health Study. Results: The CHRNA5-A3-B4 haplotypes were significantly associated with the targeted WISDM-68 scales (Tolerance, Craving, Loss of Control) in both samples of participants but only among individuals who began smoking early in life. The haplotypes were significantly associated with relapse likelihood and withdrawal severity, but these associations showed no evidence of an interaction with age at daily smoking. Discussion: The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking.

UR - http://www.scopus.com/inward/record.url?scp=67650239435&partnerID=8YFLogxK

U2 - 10.1093/ntr/ntp064

DO - 10.1093/ntr/ntp064

M3 - Article

C2 - 19436041

AN - SCOPUS:67650239435

SN - 1462-2203

VL - 11

SP - 785

EP - 796

JO - Nicotine and Tobacco Research

JF - Nicotine and Tobacco Research

IS - 7

ER -

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

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