Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose

Minju Lee, Heehong Yang, Daesan Kim, Myungjae Yang, Tai Hyun Park, Seunghun Hong

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37 Scopus citations

Abstract

We report a strategy for the human-like smelling of a rose scent utilizing olfactory receptor nanodisc (ND)-based bioelectronic nose devices. In this strategy, a floating electrode (FE)-based carbon nanotube (CNT) field effect transistor (FET) was functionalized with human olfactory receptor 1A2 (hOR1A2)-embedded NDs (hOR1A2NDs). The hOR1A2NDs responded to rose scent molecules specifically, which were monitored electrically using the underlying CNT-FET. This strategy allowed us to quantitatively assess the contents of geraniol and citronellol, the main components of a rose scent, as low as 1 fM and 10 fM, respectively. In addition, it enabled us to selectively discriminate a specific rose odorant from other odorants. Significantly, we also demonstrated that the responses of hOR1A2NDs to a rose scent could be strongly enhanced by enhancer materials like a human nose. Furthermore, the method provided a means to quantitatively evaluate rose scent components in real samples such as rose oil. Since our method allows one to quantitatively evaluate general rose scent ingredients just like a human nose, it could be a powerful strategy for versatile basic research and various applications such as fragrance development.

Original languageEnglish
Article number13945
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - 1 Dec 2018

Bibliographical note

Funding Information:
This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement No 682286). SH also acknowledges the support from the Ministry of Science and ICT (MSIT) of Korea as Global Frontier Project (Grant number H-GUARD_2013M3A6B2078961) and NRF grants (No. 2014M3A7B4051591). This research was also supported by the National Research Foundation funded by the Korean government (MSIT) (NRF-2018R1A2B3004498). The authors thank HooDeok Kim (LG Household & Health Care, Korea) for donating the natural rose oil.

Publisher Copyright:
© 2018, The Author(s).

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