Homogeneous NMR spectra in inhomogeneous fields

Sujatha Vathyam, Sanghyuk Lee, Warren S. Warren

Research output: Contribution to journalArticlepeer-review

197 Scopus citations

Abstract

Researchers interested in high-resolution nuclear magnetic resonance (NMR) spectroscopy have long sought higher magnetic fields to enhance resolution and simplify spectra. Magnets with substantially larger fields than those available in the best commercial spectrometers are available, but the inhomogeneity is unacceptable for high-resolution spectra. A detection method (termed HOMOGENIZED) is presented that removes inhomogeneity while retaining chemical shift differences and J couplings. With existing inhomogeneous magnets, this method could nearly doublethe largest resonance frequency available for high-resolution NMR. The HOMOGENIZED sequence is based on observations of intermolecular zero-quantum coherences between a solute molecule and solvent molecules that are micrometers away; as long as the field is homogeneous over this short distance, sharp resonances are recovered without echoes. Experimental demonstrations and a detailed density matrix theory to explain the effect are presented.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalScience
Volume272
Issue number5258
DOIs
StatePublished - 5 Apr 1996

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