HLA allele distribution associated with adverse drug reactions in organ transplant patients

Kye Hwa Lee; Yi Jun Kim; Hyo Jung Kim; Ju Han Kim

doi:10.3233/SHTI190680

HLA allele distribution associated with adverse drug reactions in organ transplant patients

Kye Hwa Lee, Yi Jun Kim, Hyo Jung Kim, Ju Han Kim

Department of Environmental Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The results of Human Leukocyte Antigen (HLA) antigen testing in transplant patients are not generally used to predict future adverse events. In this study, free-text HLA screening results of transplant patients were analyzed and stored in a database, and the frequencies of patients with adverse events according to HLA allele were extracted. Approximately 25% of patients had HLA alleles associated with serious drug side effects.

Original language	English
Title of host publication	MEDINFO 2019
Subtitle of host publication	Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics
Editors	Brigitte Seroussi, Lucila Ohno-Machado, Lucila Ohno-Machado, Brigitte Seroussi
Publisher	IOS Press
Pages	1851-1852
Number of pages	2
ISBN (Electronic)	9781643680026
DOIs	https://doi.org/10.3233/SHTI190680
State	Published - 21 Aug 2019
Event	17th World Congress on Medical and Health Informatics, MEDINFO 2019 - Lyon, France Duration: 25 Aug 2019 → 30 Aug 2019

Publication series

Name	Studies in Health Technology and Informatics
Volume	264
ISSN (Print)	0926-9630
ISSN (Electronic)	1879-8365

Conference

Conference	17th World Congress on Medical and Health Informatics, MEDINFO 2019
Country/Territory	France
City	Lyon
Period	25/08/19 → 30/08/19

Keywords

Adverse Reactions
Drug-Related Side Effects
HLA Antigens
Pharmacogenomic Testing

Access to Document

10.3233/SHTI190680

Cite this

Lee, K. H., Kim, Y. J., Kim, H. J., & Kim, J. H. (2019). HLA allele distribution associated with adverse drug reactions in organ transplant patients. In B. Seroussi, L. Ohno-Machado, L. Ohno-Machado, & B. Seroussi (Eds.), MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics (pp. 1851-1852). (Studies in Health Technology and Informatics; Vol. 264). IOS Press. https://doi.org/10.3233/SHTI190680

Lee, Kye Hwa ; Kim, Yi Jun ; Kim, Hyo Jung et al. / HLA allele distribution associated with adverse drug reactions in organ transplant patients. MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics. editor / Brigitte Seroussi ; Lucila Ohno-Machado ; Lucila Ohno-Machado ; Brigitte Seroussi. IOS Press, 2019. pp. 1851-1852 (Studies in Health Technology and Informatics).

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title = "HLA allele distribution associated with adverse drug reactions in organ transplant patients",

abstract = "The results of Human Leukocyte Antigen (HLA) antigen testing in transplant patients are not generally used to predict future adverse events. In this study, free-text HLA screening results of transplant patients were analyzed and stored in a database, and the frequencies of patients with adverse events according to HLA allele were extracted. Approximately 25% of patients had HLA alleles associated with serious drug side effects.",

keywords = "Adverse Reactions, Drug-Related Side Effects, HLA Antigens, Pharmacogenomic Testing",

author = "Lee, {Kye Hwa} and Kim, {Yi Jun} and Kim, {Hyo Jung} and Kim, {Ju Han}",

note = "Funding Information: This research was supported by a grant (16183MFDS541) from Ministry of Food and Drug Safety in 2018. Publisher Copyright: {\textcopyright} 2019 International Medical Informatics Association (IMIA) and IOS Press. This article is published online with Open Access by IOS Press and distributed under the terms of the Creative Commons Attribution Non-Commercial License 4.0 (CC BY-NC 4.0).; 17th World Congress on Medical and Health Informatics, MEDINFO 2019 ; Conference date: 25-08-2019 Through 30-08-2019",

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doi = "10.3233/SHTI190680",

language = "English",

series = "Studies in Health Technology and Informatics",

publisher = "IOS Press",

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Lee, KH, Kim, YJ, Kim, HJ & Kim, JH 2019, HLA allele distribution associated with adverse drug reactions in organ transplant patients. in B Seroussi, L Ohno-Machado, L Ohno-Machado & B Seroussi (eds), MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics. Studies in Health Technology and Informatics, vol. 264, IOS Press, pp. 1851-1852, 17th World Congress on Medical and Health Informatics, MEDINFO 2019, Lyon, France, 25/08/19. https://doi.org/10.3233/SHTI190680

HLA allele distribution associated with adverse drug reactions in organ transplant patients. / Lee, Kye Hwa; Kim, Yi Jun; Kim, Hyo Jung et al.
MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics. ed. / Brigitte Seroussi; Lucila Ohno-Machado; Lucila Ohno-Machado; Brigitte Seroussi. IOS Press, 2019. p. 1851-1852 (Studies in Health Technology and Informatics; Vol. 264).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lee, Kye Hwa

AU - Kim, Yi Jun

AU - Kim, Hyo Jung

AU - Kim, Ju Han

N1 - Funding Information: This research was supported by a grant (16183MFDS541) from Ministry of Food and Drug Safety in 2018. Publisher Copyright: © 2019 International Medical Informatics Association (IMIA) and IOS Press. This article is published online with Open Access by IOS Press and distributed under the terms of the Creative Commons Attribution Non-Commercial License 4.0 (CC BY-NC 4.0).

PY - 2019/8/21

Y1 - 2019/8/21

N2 - The results of Human Leukocyte Antigen (HLA) antigen testing in transplant patients are not generally used to predict future adverse events. In this study, free-text HLA screening results of transplant patients were analyzed and stored in a database, and the frequencies of patients with adverse events according to HLA allele were extracted. Approximately 25% of patients had HLA alleles associated with serious drug side effects.

AB - The results of Human Leukocyte Antigen (HLA) antigen testing in transplant patients are not generally used to predict future adverse events. In this study, free-text HLA screening results of transplant patients were analyzed and stored in a database, and the frequencies of patients with adverse events according to HLA allele were extracted. Approximately 25% of patients had HLA alleles associated with serious drug side effects.

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KW - Drug-Related Side Effects

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KW - Pharmacogenomic Testing

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Lee KH, Kim YJ, Kim HJ, Kim JH. HLA allele distribution associated with adverse drug reactions in organ transplant patients. In Seroussi B, Ohno-Machado L, Ohno-Machado L, Seroussi B, editors, MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics. IOS Press. 2019. p. 1851-1852. (Studies in Health Technology and Informatics). doi: 10.3233/SHTI190680

HLA allele distribution associated with adverse drug reactions in organ transplant patients

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