Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Sangkyung Eom; Youngmi Kim; Deokbum Park; Hansoo Lee; Yun Sil Lee; Jongseon Choe; Young Myeong Kim; Dooil Jeoung

doi:10.1074/jbc.M113.521245

Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Sangkyung Eom
, Youngmi Kim
, Deokbum Park
, Hansoo Lee
, Yun Sil Lee
, Jongseon Choe
, Young Myeong Kim
, Dooil Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

Original language	English
Pages (from-to)	12126-12144
Number of pages	19
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.521245
State	Published - 25 Apr 2014

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title = "Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis",

abstract = "Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.",

author = "Sangkyung Eom and Youngmi Kim and Deokbum Park and Hansoo Lee and Lee, \{Yun Sil\} and Jongseon Choe and Kim, \{Young Myeong\} and Dooil Jeoung",

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AU - Eom, Sangkyung

AU - Kim, Youngmi

AU - Park, Deokbum

AU - Lee, Hansoo

AU - Lee, Yun Sil

AU - Choe, Jongseon

AU - Kim, Young Myeong

AU - Jeoung, Dooil

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

AB - Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

UR - https://www.scopus.com/pages/publications/84899462385

U2 - 10.1074/jbc.M113.521245

DO - 10.1074/jbc.M113.521245

M3 - Article

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AN - SCOPUS:84899462385

SN - 0021-9258

VL - 289

SP - 12126

EP - 12144

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 17

ER -

Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Abstract

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