Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Sangkyung Eom; Youngmi Kim; Deokbum Park; Hansoo Lee; Yun Sil Lee; Jongseon Choe; Young Myeong Kim; Dooil Jeoung

doi:10.1074/jbc.M113.521245

Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Sangkyung Eom, Youngmi Kim, Deokbum Park, Hansoo Lee, Yun Sil Lee, Jongseon Choe, Young Myeong Kim, Dooil Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

Original language	English
Pages (from-to)	12126-12144
Number of pages	19
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.521245
State	Published - 25 Apr 2014

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title = "Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis",

abstract = "Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.",

author = "Sangkyung Eom and Youngmi Kim and Deokbum Park and Hansoo Lee and Lee, {Yun Sil} and Jongseon Choe and Kim, {Young Myeong} and Dooil Jeoung",

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AU - Eom, Sangkyung

AU - Kim, Youngmi

AU - Park, Deokbum

AU - Lee, Hansoo

AU - Lee, Yun Sil

AU - Choe, Jongseon

AU - Kim, Young Myeong

AU - Jeoung, Dooil

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

AB - Background: The relationship between anaphylaxis and tumor metastasis remains unknown at the molecular level.Results: The miR-384/HDAC3 axis regulates an interaction between tumor cells and mast cells. Conclusion: HDAC3 mediates a positive feedback loop between anaphylaxis and tumor metastasis. Significance: HDAC3 can be a target for the development of allergy and cancer therapeutics.

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SN - 0021-9258

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SP - 12126

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis

Abstract

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