Histological features of intracranial thrombi in stroke patients with cancer

Hyungjong Park; Jayoung Kim; Jimin Ha; In Gun Hwang; Tae Jin Song; Joonsang Yoo; Seong Hwan Ahn; Kyoungsub Kim; Byung Moon Kim; Dong Joon Kim; Young Dae Kim; Hyo Suk Nam; Il Kwon; Hyun Jung Choi; Sung Il Sohn; Hye Sun Lee; Ji Hoe Heo

doi:10.1002/ana.25495

Histological features of intracranial thrombi in stroke patients with cancer

Hyungjong Park, Jayoung Kim, Jimin Ha, In Gun Hwang, Tae Jin Song, Joonsang Yoo, Seong Hwan Ahn, Kyoungsub Kim, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam, Il Kwon, Hyun Jung Choi, Sung Il Sohn, Hye Sun Lee, Ji Hoe Heo

Department of Neurology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019.

Original language	English
Pages (from-to)	143-149
Number of pages	7
Journal	Annals of Neurology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1002/ana.25495
State	Published - Jul 2019

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant No.: HC15C1056) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996).

Publisher Copyright:
© 2019 American Neurological Association

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@article{9294c8f0689f47eaa770c6e5a4de51cf,

title = "Histological features of intracranial thrombi in stroke patients with cancer",

abstract = "The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019.",

author = "Hyungjong Park and Jayoung Kim and Jimin Ha and Hwang, {In Gun} and Song, {Tae Jin} and Joonsang Yoo and Ahn, {Seong Hwan} and Kyoungsub Kim and Kim, {Byung Moon} and Kim, {Dong Joon} and Kim, {Young Dae} and Nam, {Hyo Suk} and Il Kwon and Choi, {Hyun Jung} and Sohn, {Sung Il} and Lee, {Hye Sun} and Heo, {Ji Hoe}",

note = "Funding Information: This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant No.: HC15C1056) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996). Publisher Copyright: {\textcopyright} 2019 American Neurological Association",

year = "2019",

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doi = "10.1002/ana.25495",

language = "English",

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T1 - Histological features of intracranial thrombi in stroke patients with cancer

AU - Park, Hyungjong

AU - Kim, Jayoung

AU - Ha, Jimin

AU - Hwang, In Gun

AU - Song, Tae Jin

AU - Yoo, Joonsang

AU - Ahn, Seong Hwan

AU - Kim, Kyoungsub

AU - Kim, Byung Moon

AU - Kim, Dong Joon

AU - Kim, Young Dae

AU - Nam, Hyo Suk

AU - Kwon, Il

AU - Choi, Hyun Jung

AU - Sohn, Sung Il

AU - Lee, Hye Sun

AU - Heo, Ji Hoe

N1 - Funding Information: This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant No.: HC15C1056) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996). Publisher Copyright: © 2019 American Neurological Association

PY - 2019/7

Y1 - 2019/7

N2 - The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019.

AB - The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019.

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JO - Annals of Neurology

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Histological features of intracranial thrombi in stroke patients with cancer

Abstract

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