Histological features of intracranial thrombi in stroke patients with cancer

Hyungjong Park, Jayoung Kim, Jimin Ha, In Gun Hwang, Tae Jin Song, Joonsang Yoo, Seong Hwan Ahn, Kyoungsub Kim, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam, Il Kwon, Hyun Jung Choi, Sung Il Sohn, Hye Sun Lee, Ji Hoe Heo

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer-associated stroke. ANN NEUROL 2019.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalAnnals of Neurology
Issue number1
StatePublished - Jul 2019

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant No.: HC15C1056) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996).

Publisher Copyright:
© 2019 American Neurological Association


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