Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim; Jae Hong Lee; Sang Won Seo; Jeong Hun Kim; Joon Kyung Seong; Byoung Seok Ye; Hanna Cho; Young Noh; Hee Jin Kim; Cindy W. Yoon; Seung Jun Oh; Jae Seung Kim; Yearn Seong Choe; Kyung Han Lee; Sung Tae Kim; Jung Won Hwang; Jee Hyang Jeong; Duk L. Na

doi:10.1016/j.neurobiolaging.2014.08.009

Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim, Jae Hong Lee, Sang Won Seo, Jeong Hun Kim, Joon Kyung Seong, Byoung Seok Ye, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Jung Won Hwang, Jee Hyang Jeong, Duk L. Na

Department of Neurology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative ¹¹C-Pittsburg compound-B (PiB^-) positron emission tomography and to compare hippocampal volume and shape between PiB^- SVaD and PiB positive (PiB⁺) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB^- SVaD, 34 with PiB⁺ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB^- SVaD was significantly smaller than NC but larger than that of PiB⁺ AD (NC > PiB^- SVaD > PiB⁺ AD). Both PiB^- SVaD and PiB⁺ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB^- SVaD and PiB⁺ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB⁺ AD. PiB^- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

Original language	English
Pages (from-to)	485-491
Number of pages	7
Journal	Neurobiology of Aging
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.08.009
State	Published - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Alzheimer's disease
Hippocampus
PiB-PET
Vascular dementia

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10.1016/j.neurobiolaging.2014.08.009

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Kim, G. H., Lee, J. H., Seo, S. W., Kim, J. H., Seong, J. K., Ye, B. S., Cho, H., Noh, Y., Kim, H. J., Yoon, C. W., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K. H., Kim, S. T., Hwang, J. W., Jeong, J. H., & Na, D. L. (2015). Hippocampal volume and shape in pure subcortical vascular dementia. Neurobiology of Aging, 36(1), 485-491. https://doi.org/10.1016/j.neurobiolaging.2014.08.009

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title = "Hippocampal volume and shape in pure subcortical vascular dementia",

abstract = "The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.",

keywords = "Alzheimer's disease, Hippocampus, PiB-PET, Vascular dementia",

author = "Kim, {Geon Ha} and Lee, {Jae Hong} and Seo, {Sang Won} and Kim, {Jeong Hun} and Seong, {Joon Kyung} and Ye, {Byoung Seok} and Hanna Cho and Young Noh and Kim, {Hee Jin} and Yoon, {Cindy W.} and Oh, {Seung Jun} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Kim, {Sung Tae} and Hwang, {Jung Won} and Jeong, {Jee Hyang} and Na, {Duk L.}",

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AU - Ye, Byoung Seok

AU - Cho, Hanna

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Oh, Seung Jun

AU - Kim, Jae Seung

AU - Choe, Yearn Seong

AU - Lee, Kyung Han

AU - Kim, Sung Tae

AU - Hwang, Jung Won

AU - Jeong, Jee Hyang

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AB - The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

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KW - Hippocampus

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Hippocampal volume and shape in pure subcortical vascular dementia

Abstract

Bibliographical note

Keywords

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