Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N= 16) and PiB (+) (N= 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.
|Number of pages||10|
|Journal||Neurobiology of Aging|
|State||Published - Feb 2014|
Bibliographical noteFunding Information:
This research was supported by the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2013K000338 ), the Ministry of Health and Welfare, Korea (no. A102065), and a Samsung Medical Center Clinical Research Program Grant ( CRL-108011 & CRS 110-14-1 ).
- Alzheimer's disease
- Cortical thickness
- Mild cognitive impairment
- Pittsburgh compound B