Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study

Hanna Cho; Seun Jeon; Changsoo Kim; Byoung Seok Ye; Geon Ha Kim; Young Noh; Hee Jin Kim; Cindy W. Yoon; Yeo Jin Kim; Jung Hyun Kim; Sang Eon Park; Sung Tae Kim; Jong Min Lee; Sue J. Kang; Mee Kyung Suh; Juhee Chin; Duk L. Na; Dae Ryong Kang; Sang Won Seo

doi:10.1017/S1041610214001483

Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study

Hanna Cho, Seun Jeon, Changsoo Kim, Byoung Seok Ye, Geon Ha Kim, Young Noh, Hee Jin Kim, Cindy W. Yoon, Yeo Jin Kim, Jung Hyun Kim, Sang Eon Park, Sung Tae Kim, Jong Min Lee, Sue J. Kang, Mee Kyung Suh, Juhee Chin, Duk L. Na, Dae Ryong Kang, Sang Won Seo

Department of Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

Original language	English
Pages (from-to)	111-120
Number of pages	10
Journal	International Psychogeriatrics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1017/S1041610214001483
State	Published - 12 Jan 2015

Bibliographical note

Publisher Copyright:
Copyright © 2014 International Psychogeriatric Association.

Keywords

Alzheimer's disease
cognitive reserve theory
cortical thickness
education

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10.1017/S1041610214001483

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Cho, H., Jeon, S., Kim, C., Ye, B. S., Kim, G. H., Noh, Y., Kim, H. J., Yoon, C. W., Kim, Y. J., Kim, J. H., Park, S. E., Kim, S. T., Lee, J. M., Kang, S. J., Suh, M. K., Chin, J., Na, D. L., Kang, D. R., & Seo, S. W. (2015). Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study. International Psychogeriatrics, 27(1), 111-120. https://doi.org/10.1017/S1041610214001483

@article{a4e6806835f4429fa4705cdc4c44e902,

title = "Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study",

abstract = "Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.",

keywords = "Alzheimer's disease, cognitive reserve theory, cortical thickness, education",

author = "Hanna Cho and Seun Jeon and Changsoo Kim and Ye, {Byoung Seok} and Kim, {Geon Ha} and Young Noh and Kim, {Hee Jin} and Yoon, {Cindy W.} and Kim, {Yeo Jin} and Kim, {Jung Hyun} and Park, {Sang Eon} and Kim, {Sung Tae} and Lee, {Jong Min} and Kang, {Sue J.} and Suh, {Mee Kyung} and Juhee Chin and Na, {Duk L.} and Kang, {Dae Ryong} and Seo, {Sang Won}",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 International Psychogeriatric Association.",

year = "2015",

month = jan,

day = "12",

doi = "10.1017/S1041610214001483",

language = "English",

volume = "27",

pages = "111--120",

journal = "International Psychogeriatrics",

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Cho, H, Jeon, S, Kim, C, Ye, BS, Kim, GH, Noh, Y, Kim, HJ, Yoon, CW, Kim, YJ, Kim, JH, Park, SE, Kim, ST, Lee, JM, Kang, SJ, Suh, MK, Chin, J, Na, DL, Kang, DR & Seo, SW 2015, 'Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study', International Psychogeriatrics, vol. 27, no. 1, pp. 111-120. https://doi.org/10.1017/S1041610214001483

TY - JOUR

T1 - Higher education affects accelerated cortical thinning in Alzheimer's disease

T2 - A 5-year preliminary longitudinal study

AU - Cho, Hanna

AU - Jeon, Seun

AU - Kim, Changsoo

AU - Ye, Byoung Seok

AU - Kim, Geon Ha

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Kim, Yeo Jin

AU - Kim, Jung Hyun

AU - Park, Sang Eon

AU - Kim, Sung Tae

AU - Lee, Jong Min

AU - Kang, Sue J.

AU - Suh, Mee Kyung

AU - Chin, Juhee

AU - Na, Duk L.

AU - Kang, Dae Ryong

AU - Seo, Sang Won

PY - 2015/1/12

Y1 - 2015/1/12

N2 - Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

AB - Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

KW - Alzheimer's disease

KW - cognitive reserve theory

KW - cortical thickness

KW - education

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U2 - 10.1017/S1041610214001483

DO - 10.1017/S1041610214001483

M3 - Article

C2 - 25226082

AN - SCOPUS:84927641765

SN - 1041-6102

VL - 27

SP - 111

EP - 120

JO - International Psychogeriatrics

JF - International Psychogeriatrics

IS - 1

ER -

Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study

Abstract

Bibliographical note

Keywords

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