High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Jeonghoon Yoon, Jeiwon Cho, Namgon Kim, Dae Duk Kim, Eunsook Lee, Changyul Cheon, Youngwoo Kwon

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.

Original languageEnglish
Pages (from-to)1970-1978
Number of pages9
JournalInternational Journal of Cancer
Volume129
Issue number8
DOIs
StatePublished - 15 Oct 2011

Keywords

  • breast cancer
  • collateral damage
  • microwave ablation
  • nude mouse xenograft model
  • planar coaxial probe-based applicator

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