High dietary glycemic load is associated with poor functional outcome in patients with acute cerebral infarction

Tae Jin Song, Yoonkyung Chang, Min Young Chun, Chan Young Lee, A. Ram Kim, Yuri Kim, Yong Jae Kim

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background and Purpose Elevated postprandial blood glucose is a critical risk factor for stroke. The dietary glycemic load (GL) and glycemic index (GI) are frequently used as markers of the postprandial blood glucose response to estimate the overall glycemic effect of diets. We hypothesized that high dietary GL, GI, or total carbohydrate intake is associated with a poor functional outcome in patients with acute ischemic stroke. Methods We prospectively included 263 first-ever ischemic stroke patients who completed a semiquantitative food-frequency questionnaire. The dietary GL, GI, and total carbohydrate intake were investigated by examining the average frequency of intake during the previous year based on reference amounts for various food items. Poor functional outcome was defined as a score on the modified Rankin Scale (mRS) of ≥3 at 3 months after stroke. Results The patients were aged 65.4±11.7 years (mean±standard deviation), and 58.2% of them were male. A multivariate analysis adjusted for age, sex, marital status, prestroke mRS score, diabetes mellitus, hyperlipidemia, body mass index, triglycerides, low-density lipopro-tein, hemoglobin A1c, stroke classification, and National Institutes of Health Stroke Scale score, early neurological deterioration, and high-grade white-matter hyperintensities revealed that the dietary GL and total carbohydrate intake were associated with a poor functional outcome, with odds ratios for the top quartile relative to the bottom quartile of 28.93 (95% confidence interval= 2.82–296.04) and 36.84 (95% confidence interval=2.99–453.42), respectively (p for trend=0.002 and 0.002, respectively). In contrast, high dietary GI was not associated with a poor functional outcome (p for trend=0.481). Conclusions Increased dietary GL and carbohydrate intake were associated with a poor short-term functional outcome after an acute ischemic stroke.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalJournal of Clinical Neurology (Korea)
Volume14
Issue number2
DOIs
StatePublished - Apr 2018

Keywords

  • Carbohydrate intake
  • Glycemic index
  • Glycemic load
  • Outcome
  • Stroke

Fingerprint

Dive into the research topics of 'High dietary glycemic load is associated with poor functional outcome in patients with acute cerebral infarction'. Together they form a unique fingerprint.

Cite this