Abstract
Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.
Original language | English |
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Pages (from-to) | 112-115 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 388 |
Issue number | 2 |
DOIs | |
State | Published - 11 Nov 2005 |
Keywords
- BDNF
- Dopamine
- ELISA
- Methamphetamine
- Neurotoxicity