High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim; Sungwon Roh; Yujung Kim; Su Jung Yoon; Hae Kook Lee; Chang Su Han; Yong Ku Kim

doi:10.1016/j.neulet.2005.06.042

High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim, Sungwon Roh, Yujung Kim, Su Jung Yoon, Hae Kook Lee, Chang Su Han, Yong Ku Kim

Ewha Brain Institute

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

Original language	English
Pages (from-to)	112-115
Number of pages	4
Journal	Neuroscience Letters
Volume	388
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2005.06.042
State	Published - 11 Nov 2005

Keywords

BDNF
Dopamine
ELISA
Methamphetamine
Neurotoxicity

Access to Document

10.1016/j.neulet.2005.06.042

Cite this

@article{6c2c7825df324f49b9516c06d07f3e55,

title = "High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users",

abstract = "Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.",

keywords = "BDNF, Dopamine, ELISA, Methamphetamine, Neurotoxicity",

author = "Kim, {Dai Jin} and Sungwon Roh and Yujung Kim and Yoon, {Su Jung} and Lee, {Hae Kook} and Han, {Chang Su} and Kim, {Yong Ku}",

note = "Funding Information: The authors acknowledge financial support from the Catholic Medical Center Research Foundation that was made in the program year of 2004. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0405-NS01-0704-0001). ",

year = "2005",

month = nov,

day = "11",

doi = "10.1016/j.neulet.2005.06.042",

language = "English",

volume = "388",

pages = "112--115",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

AU - Kim, Dai Jin

AU - Roh, Sungwon

AU - Kim, Yujung

AU - Yoon, Su Jung

AU - Lee, Hae Kook

AU - Han, Chang Su

AU - Kim, Yong Ku

N1 - Funding Information: The authors acknowledge financial support from the Catholic Medical Center Research Foundation that was made in the program year of 2004. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0405-NS01-0704-0001).

PY - 2005/11/11

Y1 - 2005/11/11

N2 - Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

AB - Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

KW - BDNF

KW - Dopamine

KW - ELISA

KW - Methamphetamine

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=23944504295&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2005.06.042

DO - 10.1016/j.neulet.2005.06.042

M3 - Article

C2 - 16039058

AN - SCOPUS:23944504295

SN - 0304-3940

VL - 388

SP - 112

EP - 115

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Abstract

Keywords

Access to Document

Fingerprint

Cite this