High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim, Sungwon Roh, Yujung Kim, Su Jung Yoon, Hae Kook Lee, Chang Su Han, Yong Ku Kim

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Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - 11 Nov 2005

Bibliographical note

Funding Information:
The authors acknowledge financial support from the Catholic Medical Center Research Foundation that was made in the program year of 2004. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0405-NS01-0704-0001).


  • BDNF
  • Dopamine
  • Methamphetamine
  • Neurotoxicity


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