High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim; Sungwon Roh; Yujung Kim; Su Jung Yoon; Hae Kook Lee; Chang Su Han; Yong Ku Kim

doi:10.1016/j.neulet.2005.06.042

High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Dai Jin Kim, Sungwon Roh, Yujung Kim, Su Jung Yoon, Hae Kook Lee, Chang Su Han, Yong Ku Kim

Ewha Brain Institute

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.

Original language	English
Pages (from-to)	112-115
Number of pages	4
Journal	Neuroscience Letters
Volume	388
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2005.06.042
State	Published - 11 Nov 2005

Bibliographical note

Funding Information:
The authors acknowledge financial support from the Catholic Medical Center Research Foundation that was made in the program year of 2004. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0405-NS01-0704-0001).

Keywords

BDNF
Dopamine
ELISA
Methamphetamine
Neurotoxicity

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10.1016/j.neulet.2005.06.042

Cite this

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title = "High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users",

abstract = "Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.",

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note = "Funding Information: The authors acknowledge financial support from the Catholic Medical Center Research Foundation that was made in the program year of 2004. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0405-NS01-0704-0001). ",

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AU - Yoon, Su Jung

AU - Lee, Hae Kook

AU - Han, Chang Su

AU - Kim, Yong Ku

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High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

Abstract

Bibliographical note

Keywords

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