Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Nahyun Kwon, Kwang H. Kim, Sinyoung Park, Yejin Cho, Eun Yeong Park, Junha Lim, Seda Çetindere, Süreyya Oğuz Tümay, Won Jong Kim, Xingshu Li, Ki Taek Nam, Chulhong Kim, Serkan Yeşilot, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.

Original languageEnglish
Article number114612
JournalBiosensors and Bioelectronics
Volume216
DOIs
StatePublished - 15 Nov 2022

Bibliographical note

Funding Information:
J.Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 ). X. L. thanks the National Natural Science Foundation of China (Grant No. 22078066 ). K.T.N thanks the National Research Foundation of Korea (NRF) grant founded by the Korea Mouse Phenotyping Project ( NRF-2016M3A9D5A01952416 ). C.K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A1A03047902 ). N. K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A3A03040525 ).

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

  • Dual-modal imaging
  • NIR fluorescence Imaging
  • Photoacoustic imaging
  • Photothermal cancer therapy
  • Theragnostic nanoparticle

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