TY - JOUR
T1 - Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy
AU - Kwon, Nahyun
AU - Kim, Kwang H.
AU - Park, Sinyoung
AU - Cho, Yejin
AU - Park, Eun Yeong
AU - Lim, Junha
AU - Çetindere, Seda
AU - Tümay, Süreyya Oğuz
AU - Kim, Won Jong
AU - Li, Xingshu
AU - Nam, Ki Taek
AU - Kim, Chulhong
AU - Yeşilot, Serkan
AU - Yoon, Juyoung
N1 - Funding Information:
J.Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 ). X. L. thanks the National Natural Science Foundation of China (Grant No. 22078066 ). K.T.N thanks the National Research Foundation of Korea (NRF) grant founded by the Korea Mouse Phenotyping Project ( NRF-2016M3A9D5A01952416 ). C.K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A1A03047902 ). N. K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A3A03040525 ).
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/11/15
Y1 - 2022/11/15
N2 - Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
AB - Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
KW - Dual-modal imaging
KW - NIR fluorescence Imaging
KW - Photoacoustic imaging
KW - Photothermal cancer therapy
KW - Theragnostic nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85135726499&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2022.114612
DO - 10.1016/j.bios.2022.114612
M3 - Article
C2 - 35952434
AN - SCOPUS:85135726499
SN - 0956-5663
VL - 216
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 114612
ER -