Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Nahyun Kwon; Kwang H. Kim; Sinyoung Park; Yejin Cho; Eun Yeong Park; Junha Lim; Seda Çetindere; Süreyya Oğuz Tümay; Won Jong Kim; Xingshu Li; Ki Taek Nam; Chulhong Kim; Serkan Yeşilot; Juyoung Yoon

doi:10.1016/j.bios.2022.114612

Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Nahyun Kwon, Kwang H. Kim, Sinyoung Park, Yejin Cho, Eun Yeong Park, Junha Lim, Seda Çetindere, Süreyya Oğuz Tümay, Won Jong Kim, Xingshu Li, Ki Taek Nam, Chulhong Kim, Serkan Yeşilot, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.

Original language	English
Article number	114612
Journal	Biosensors and Bioelectronics
Volume	216
DOIs	https://doi.org/10.1016/j.bios.2022.114612
State	Published - 15 Nov 2022

Bibliographical note

Funding Information:
J.Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 ). X. L. thanks the National Natural Science Foundation of China (Grant No. 22078066 ). K.T.N thanks the National Research Foundation of Korea (NRF) grant founded by the Korea Mouse Phenotyping Project ( NRF-2016M3A9D5A01952416 ). C.K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A1A03047902 ). N. K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A3A03040525 ).

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

Dual-modal imaging
NIR fluorescence Imaging
Photoacoustic imaging
Photothermal cancer therapy
Theragnostic nanoparticle

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10.1016/j.bios.2022.114612

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Kwon, N., Kim, K. H., Park, S., Cho, Y., Park, E. Y., Lim, J., Çetindere, S., Tümay, S. O., Kim, W. J., Li, X., Nam, K. T., Kim, C., Yeşilot, S., & Yoon, J. (2022). Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy. Biosensors and Bioelectronics, 216, Article 114612. https://doi.org/10.1016/j.bios.2022.114612

@article{760c777e4ed149078ef7aad54abfe3c9,

title = "Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy",

abstract = "Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, {\textquoteleft}safe{\textquoteright} fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.",

keywords = "Dual-modal imaging, NIR fluorescence Imaging, Photoacoustic imaging, Photothermal cancer therapy, Theragnostic nanoparticle",

author = "Nahyun Kwon and Kim, {Kwang H.} and Sinyoung Park and Yejin Cho and Park, {Eun Yeong} and Junha Lim and Seda {\c C}etindere and T{\"u}may, {S{\"u}reyya Oğuz} and Kim, {Won Jong} and Xingshu Li and Nam, {Ki Taek} and Chulhong Kim and Serkan Ye{\c s}ilot and Juyoung Yoon",

note = "Funding Information: J.Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 ). X. L. thanks the National Natural Science Foundation of China (Grant No. 22078066 ). K.T.N thanks the National Research Foundation of Korea (NRF) grant founded by the Korea Mouse Phenotyping Project ( NRF-2016M3A9D5A01952416 ). C.K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A1A03047902 ). N. K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A3A03040525 ). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = nov,

day = "15",

doi = "10.1016/j.bios.2022.114612",

language = "English",

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Kwon, N, Kim, KH, Park, S, Cho, Y, Park, EY, Lim, J, Çetindere, S, Tümay, SO, Kim, WJ, Li, X, Nam, KT, Kim, C, Yeşilot, S & Yoon, J 2022, 'Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy', Biosensors and Bioelectronics, vol. 216, 114612. https://doi.org/10.1016/j.bios.2022.114612

TY - JOUR

T1 - Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

AU - Kwon, Nahyun

AU - Kim, Kwang H.

AU - Park, Sinyoung

AU - Cho, Yejin

AU - Park, Eun Yeong

AU - Lim, Junha

AU - Çetindere, Seda

AU - Tümay, Süreyya Oğuz

AU - Kim, Won Jong

AU - Li, Xingshu

AU - Nam, Ki Taek

AU - Kim, Chulhong

AU - Yeşilot, Serkan

AU - Yoon, Juyoung

N1 - Funding Information: J.Y. thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 ). X. L. thanks the National Natural Science Foundation of China (Grant No. 22078066 ). K.T.N thanks the National Research Foundation of Korea (NRF) grant founded by the Korea Mouse Phenotyping Project ( NRF-2016M3A9D5A01952416 ). C.K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A1A03047902 ). N. K. thanks the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2020R1A6A3A03040525 ). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/11/15

Y1 - 2022/11/15

N2 - Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.

AB - Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, ‘safe’ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.

KW - Dual-modal imaging

KW - NIR fluorescence Imaging

KW - Photoacoustic imaging

KW - Photothermal cancer therapy

KW - Theragnostic nanoparticle

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U2 - 10.1016/j.bios.2022.114612

DO - 10.1016/j.bios.2022.114612

M3 - Article

C2 - 35952434

AN - SCOPUS:85135726499

SN - 0956-5663

VL - 216

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

M1 - 114612

ER -

Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Abstract

Bibliographical note

Keywords

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