@article{1c8538e674c546c1940d3fd37d376997,
title = "Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV",
abstract = "Severe fever with thrombocytopenia syndrome virus was first discovered in 2009 as the causative agent of severe fever with thrombocytopenia syndrome. Despite its potential threat to public health, no prophylactic vaccine is yet available. This study developed a heterologous prime-boost strategy comprising priming with recombinant replication-deficient human adenovirus type 5 (rAd5) expressing the surface glycoprotein, Gn, and boosting with Gn protein. This vaccination regimen induced balanced Th1/Th2 immune responses and resulted in potent humoral and T cell-mediated responses in mice. It elicited high neutralizing antibody titers in both mice and non-human primates. Transcriptome analysis revealed that rAd5 and Gn proteins induced adaptive and innate immune pathways, respectively. This study provides immunological and mechanistic insight into this heterologous regimen and paves the way for future strategies against emerging infectious diseases.",
author = "Kim, {Jae Yong} and Kyeongseok Jeon and Hong, {Jung Joo} and Park, {Sang In} and Hyeonggon Cho and Park, {Hyo Jung} and Kwak, {Hye Won} and Park, {Hyeong Jun} and Bang, {Yoo Jin} and Lee, {Yu Sun} and Bae, {Seo Hyeon} and Kim, {So Hee} and Hwang, {Kyung Ah} and Jung, {Dae Im} and Cho, {Seong Hoo} and Seo, {Sang Hwan} and Green Kim and Hanseul Oh and Lee, {Hwal Yong} and Kim, {Ki Hyun} and Lim, {Hee Young} and Pyeonghwa Jeon and Lee, {Joo Yeon} and Junho Chung and Lee, {Sang Myeong} and Ko, {Hae Li} and Manki Song and Cho, {Nam Hyuk} and Lee, {Young suk} and Hong, {So Hee} and Nam, {Jae Hwan}",
note = "Funding Information: J-H. N was supported by funding from the Research Unit of Korea Center for Disease Control and Prevention (Grant Numbers 2020-ER5303-00 and 2022-NI-045-00). J J.H. was supported by the Korea Research Institute of Bioscience and Biotechnology Research Initiative Programs (Grant Number KGM 4572121). S-H.H was supported by the Bio and medical technology development program of the National Research Foundation of Korea (NRF) Grant funded by the Korean government (Grant Number 2022M3E5F1016595). H-J. Park was supported by a grant from the Ministry of Food and Drug Safety in 2022 (Grant Number 22203MFDS404). Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41598-023-35328-9",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}