Heterogeneous living donor hepatic fat distribution on MRI chemical shift imaging

Young Rok Choi, Jeong Min Lee, Nam Joon Yi, Hyeyoung Kim, Min Su Park, Geun Hong, Tae Yoo, Suk Won Suh, Hae Won Lee, Kwang Woong Lee, Kyung Suk Suh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: We evaluated the heterogeneity of steatosis in living donor livers to determine its regional differences. Methods: Between June 2011 and February 2012, 81 liver donors were selected. Fat fraction was estimated using magnetic resonance triple-echo chemical shifting gradient imaging in 13 different regions: segment 1 (S1), S2, S3, and each peripheral and deep region of S4, S5, S6, S7, and S8. Results: There were differences (range, 3.2%-5.3%) in fat fractions between each peripheral and deep region of S4, S6, S7, and S8 (P < 0.001, P = 0.004, P < 0.001, and P = 0.006). Fat deposit amount in S1, S2, S3 and deep regions of S4-S8 were significantly different from one another (F [4.003, 58.032] = 8.684, P < 0.001), while there were no differences among the peripheral regions of S4-S8 (F [2.9, 5.3] = 1.3, P = 0.272) by repeated measure analysis of variance method. And regional differences of the amount of fat deposit in the whole liver increased as a peripheral fat fraction of S5 increased (R2 = 0.428, P < 0.001). Conclusion: Multifocal fat measurements for the whole liver are needed because a small regional evaluation might not represent the remaining liver completely, especially in patients with severe hepatic steatosis.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalAnnals of Surgical Treatment and Research
Volume89
Issue number1
DOIs
StatePublished - 1 Jul 2015

Keywords

  • Fatty liver
  • Liver transplantation
  • Magnetic resonance imaging
  • Transplant donor site

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