Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca²⁺ Homeostasis

Agriculture & Biology

• hesperidin 91%
• prostatic neoplasms 90%
• neoplasm cells 60%
• homeostasis 56%
• oxidative stress 52%
• calcium 41%
• cell proliferation 23%
• borates 16%
• therapeutics 15%
• biphenyl 13%
• cancer therapy 9%
• antineoplastic activity 9%
• proliferating cell nuclear antigen 9%
• phosphatidylinositol 3-kinase 8%
• cisplatin 8%
• endoplasmic reticulum stress 8%
• citrus fruits 7%
• drug resistance 7%
• mitogen-activated protein kinase 7%
• inositols 7%
• mitochondrial membrane 6%
• adjuvants 6%
• androgens 6%
• cell death 6%
• cell cycle 5%
• reactive oxygen species 5%
• adverse effects 5%
• flavonoids 5%
• neoplasms 5%
• carbohydrates 4%
• receptors 4%
• cells 2%

Medicine & Life Sciences

• Hesperidin 100%
• Prostatic Neoplasms 52%
• Oxidative Stress 48%
• Homeostasis 48%
• Borates 20%
• Cell Proliferation 17%
• diphenyl 16%
• PC-3 Cells 16%
• Citrus 8%
• Inositol 1,4,5-Trisphosphate Receptors 8%
• Endoplasmic Reticulum Stress 7%
• Mitochondrial Membranes 7%
• Proliferating Cell Nuclear Antigen 7%
• Flavonoids 6%
• Phosphatidylinositol 3-Kinase 6%
• Mitogen-Activated Protein Kinases 6%
• Antineoplastic Agents 6%
• Drug Resistance 6%
• Androgens 6%
• Cisplatin 5%
• Carbohydrates 5%
• Therapeutic Uses 5%
• Reactive Oxygen Species 5%
• Cell Cycle 5%
• Cell Death 5%
• Therapeutics 4%
• Neoplasms 4%
• Mortality 3%

Chemical Compounds

• Hesperidin 96%
• Oxidative Stress 65%
• Borate 12%
• Phosphoinositide 9%
• Androgen 8%
• Adjuvant 8%
• Inositol 7%
• Depolarization 7%
• Cisplatin 7%
• Cell Death 7%
• Antiproliferative 6%
• Flavonoid 6%
• Reactive Oxygen Metabolite 6%
• Antineoplastic Agent 5%
• Marker 5%
• Antigen 5%
• Carbohydrate 5%
• Protein 2%