Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats

Hwa Kyung Lim, Hack Seang Kim, Hong Serck Choi, Seikwan Oh, Jongwon Choi

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119 Scopus citations

Abstract

The hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, were evaluated against carbon tetrachloride (CCl4)- induced liver damage in rats. Bergenin at a dose of 50, 100 or 200 mg/kg was administered orally once daily for successive 7 days and then a mixture of 0.5 ml/kg (ip) of CCl4 in olive oil (1:1) was injected two times each at 12 and 36 h after the final administration of bergenin. The substantially elevated serum enzymatic activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and γ-glutamyltransferase due to CCl4 treatment were dose dependently restored towards normalization. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. In addition, bergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content in the liver of CCl4-intoxicated rats in a dose dependent fashion. The results of this study clearly indicate that bergenin has a potent hepatoprotective action against CCl4-induced hepatic damage in rats. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalJournal of Ethnopharmacology
Volume72
Issue number3
DOIs
StatePublished - Oct 2000

Keywords

  • Bergenin
  • Carbon tetrachloride
  • Hepatoprotective effect
  • Mallotus japonicus

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