Abstract
Ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein-protein interaction.
Original language | English |
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Pages (from-to) | 73-80 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 557 |
Issue number | 1-3 |
DOIs | |
State | Published - 16 Jan 2004 |
Keywords
- Hepatitis B virus X protein
- Peroxisome proliferator-activated receptor γ
- Protein-protein interaction
- Transactivation