TY - JOUR
T1 - Hepatic non-parenchymal cells
T2 - Master regulators of alcoholic liver disease?
AU - Seo, Wonhyo
AU - Jeong, Won Il
N1 - Funding Information:
Supported by A grant from the Next-Generation BioGreen 21 Program, No. PJ009957; Rural Development Administration; and partially from the Korea Advanced Institute of Science and Technology Institute for the BioCentury, South Korea.
Publisher Copyright:
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2016/1/28
Y1 - 2016/1/28
N2 - Chronic alcohol consumption is one of the most common causes of the progression of alcoholic liver disease (ALD). In the past, alcohol-mediated hepatocyte injury was assumed to be a significantly major cause of ALD. However, a huge number of recent and brilliant studies have demonstrated that hepatic non-parenchymal cells including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells and diverse types of lymphocytes play crucial roles in the pathogenesis of ALD by producing inflammatory mediators such as cytokines, oxidative stress, microRNA, and lipid-originated metabolites (retinoic acid and endocannabinoids) or by directly interacting with parenchymal cells (hepatocytes). Therefore, understanding the comprehensive roles of hepatic non-parenchymal cells during the development of ALD will provide new integrative directions for the treatment of ALD. This review will address the roles of non-parenchymal cells in alcoholic steatosis, inflammation, and liver fibrosis and might help us to discover possible therapeutic targets and treatments involving modulating the non-parenchymal cells in ALD.
AB - Chronic alcohol consumption is one of the most common causes of the progression of alcoholic liver disease (ALD). In the past, alcohol-mediated hepatocyte injury was assumed to be a significantly major cause of ALD. However, a huge number of recent and brilliant studies have demonstrated that hepatic non-parenchymal cells including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells and diverse types of lymphocytes play crucial roles in the pathogenesis of ALD by producing inflammatory mediators such as cytokines, oxidative stress, microRNA, and lipid-originated metabolites (retinoic acid and endocannabinoids) or by directly interacting with parenchymal cells (hepatocytes). Therefore, understanding the comprehensive roles of hepatic non-parenchymal cells during the development of ALD will provide new integrative directions for the treatment of ALD. This review will address the roles of non-parenchymal cells in alcoholic steatosis, inflammation, and liver fibrosis and might help us to discover possible therapeutic targets and treatments involving modulating the non-parenchymal cells in ALD.
KW - Alcoholic liver disease
KW - Endocannabinoid
KW - NADPH oxidase
KW - Reactive oxygen stress
UR - http://www.scopus.com/inward/record.url?scp=84994719594&partnerID=8YFLogxK
U2 - 10.3748/WJG.V22.I4.1348
DO - 10.3748/WJG.V22.I4.1348
M3 - Review article
C2 - 26819504
AN - SCOPUS:84994719594
SN - 1007-9327
VL - 22
SP - 1348
EP - 1356
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 4
ER -