Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease?

Wonhyo Seo, Won Il Jeong

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Chronic alcohol consumption is one of the most common causes of the progression of alcoholic liver disease (ALD). In the past, alcohol-mediated hepatocyte injury was assumed to be a significantly major cause of ALD. However, a huge number of recent and brilliant studies have demonstrated that hepatic non-parenchymal cells including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells and diverse types of lymphocytes play crucial roles in the pathogenesis of ALD by producing inflammatory mediators such as cytokines, oxidative stress, microRNA, and lipid-originated metabolites (retinoic acid and endocannabinoids) or by directly interacting with parenchymal cells (hepatocytes). Therefore, understanding the comprehensive roles of hepatic non-parenchymal cells during the development of ALD will provide new integrative directions for the treatment of ALD. This review will address the roles of non-parenchymal cells in alcoholic steatosis, inflammation, and liver fibrosis and might help us to discover possible therapeutic targets and treatments involving modulating the non-parenchymal cells in ALD.

Original languageEnglish
Pages (from-to)1348-1356
Number of pages9
JournalWorld Journal of Gastroenterology
Volume22
Issue number4
DOIs
StatePublished - 28 Jan 2016

Keywords

  • Alcoholic liver disease
  • Endocannabinoid
  • NADPH oxidase
  • Reactive oxygen stress

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