Heparin-Coated gold nanopartieles for liver-Specific CT imaging

In Cheol Sun; Dae Kyung Eun; Jin Hee Na; Seulki Lee; I. I.Jin Kim; In Chan Youn; Chang Yong Ko; Han Sung Kim; Dohyung Lim; Kuiwon Choi; Phillip B. Messersmith; Tae Gwan Park; Sang Yoon Kim; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/chem.200902344

Heparin-Coated gold nanopartieles for liver-Specific CT imaging

In Cheol Sun
, Dae Kyung Eun
, Jin Hee Na
, Seulki Lee
, I. I.Jin Kim
, In Chan Youn
, Chang Yong Ko
, Han Sung Kim
, Dohyung Lim
, Kuiwon Choi
, Phillip B. Messersmith
, Tae Gwan Park
, Sang Yoon Kim
, Ick Chan Kwon
, Kwangmeyung Kim
, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

"Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

Original language	English
Pages (from-to)	13341-13347+13276
Journal	Chemistry - A European Journal
Volume	15
Issue number	48
DOIs	https://doi.org/10.1002/chem.200902344
State	Published - 14 Dec 2009

Keywords

Computed tomography
Gold
Heparin
Imaging agents
Nanoparticles

Access to Document

10.1002/chem.200902344

Cite this

@article{e3b3c5f245af46c6b89df3d21b643904,

title = "Heparin-Coated gold nanopartieles for liver-Specific CT imaging",

abstract = "{"}Chemical Equation Presented{"} Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).",

keywords = "Computed tomography, Gold, Heparin, Imaging agents, Nanoparticles",

author = "Sun, \{In Cheol\} and Eun, \{Dae Kyung\} and Na, \{Jin Hee\} and Seulki Lee and Kim, \{I. I.Jin\} and Youn, \{In Chan\} and Ko, \{Chang Yong\} and Kim, \{Han Sung\} and Dohyung Lim and Kuiwon Choi and Messersmith, \{Phillip B.\} and Park, \{Tae Gwan\} and Kim, \{Sang Yoon\} and Kwon, \{Ick Chan\} and Kwangmeyung Kim and Ahn, \{Cheol Hee\}",

year = "2009",

month = dec,

day = "14",

doi = "10.1002/chem.200902344",

language = "English",

volume = "15",

pages = "13341--13347+13276",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "John Wiley and Sons Inc.",

number = "48",

}

TY - JOUR

T1 - Heparin-Coated gold nanopartieles for liver-Specific CT imaging

AU - Sun, In Cheol

AU - Eun, Dae Kyung

AU - Na, Jin Hee

AU - Lee, Seulki

AU - Kim, I. I.Jin

AU - Youn, In Chan

AU - Ko, Chang Yong

AU - Kim, Han Sung

AU - Lim, Dohyung

AU - Choi, Kuiwon

AU - Messersmith, Phillip B.

AU - Park, Tae Gwan

AU - Kim, Sang Yoon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2009/12/14

Y1 - 2009/12/14

N2 - "Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

AB - "Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

KW - Computed tomography

KW - Gold

KW - Heparin

KW - Imaging agents

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/72449120332

U2 - 10.1002/chem.200902344

DO - 10.1002/chem.200902344

M3 - Article

C2 - 19902441

AN - SCOPUS:72449120332

SN - 0947-6539

VL - 15

SP - 13341-13347+13276

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 48

ER -

Heparin-Coated gold nanopartieles for liver-Specific CT imaging

Abstract

Keywords

Access to Document

Fingerprint

Cite this