Heparin-Coated gold nanopartieles for liver-Specific CT imaging

In Cheol Sun; Dae Kyung Eun; Jin Hee Na; Seulki Lee; I. I.Jin Kim; In Chan Youn; Chang Yong Ko; Han Sung Kim; Dohyung Lim; Kuiwon Choi; Phillip B. Messersmith; Tae Gwan Park; Sang Yoon Kim; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/chem.200902344

Heparin-Coated gold nanopartieles for liver-Specific CT imaging

In Cheol Sun, Dae Kyung Eun, Jin Hee Na, Seulki Lee, I. I.Jin Kim, In Chan Youn, Chang Yong Ko, Han Sung Kim, Dohyung Lim, Kuiwon Choi, Phillip B. Messersmith, Tae Gwan Park, Sang Yoon Kim, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

"Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

Original language	English
Pages (from-to)	13341-13347+13276
Journal	Chemistry - A European Journal
Volume	15
Issue number	48
DOIs	https://doi.org/10.1002/chem.200902344
State	Published - 14 Dec 2009

Keywords

Computed tomography
Gold
Heparin
Imaging agents
Nanoparticles

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10.1002/chem.200902344

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title = "Heparin-Coated gold nanopartieles for liver-Specific CT imaging",

abstract = "{"}Chemical Equation Presented{"} Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).",

keywords = "Computed tomography, Gold, Heparin, Imaging agents, Nanoparticles",

author = "Sun, {In Cheol} and Eun, {Dae Kyung} and Na, {Jin Hee} and Seulki Lee and Kim, {I. I.Jin} and Youn, {In Chan} and Ko, {Chang Yong} and Kim, {Han Sung} and Dohyung Lim and Kuiwon Choi and Messersmith, {Phillip B.} and Park, {Tae Gwan} and Kim, {Sang Yoon} and Kwon, {Ick Chan} and Kwangmeyung Kim and Ahn, {Cheol Hee}",

year = "2009",

month = dec,

day = "14",

doi = "10.1002/chem.200902344",

language = "English",

volume = "15",

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journal = "Chemistry - A European Journal",

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T1 - Heparin-Coated gold nanopartieles for liver-Specific CT imaging

AU - Sun, In Cheol

AU - Eun, Dae Kyung

AU - Na, Jin Hee

AU - Lee, Seulki

AU - Kim, I. I.Jin

AU - Youn, In Chan

AU - Ko, Chang Yong

AU - Kim, Han Sung

AU - Lim, Dohyung

AU - Choi, Kuiwon

AU - Messersmith, Phillip B.

AU - Park, Tae Gwan

AU - Kim, Sang Yoon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2009/12/14

Y1 - 2009/12/14

N2 - "Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

AB - "Chemical Equation Presented" Gold nanoprobe: Heparin-DOPAcoated gold nanoparticles (HEPAAuNPs) showed low toxicity, prolonged stability, and an enhanced Xray absorption coefficient in vitro. In vivo microCT images showed that HEPA-AuNPs produced enhanced liver-specific CT images compared with iodine-based contrast agents, thus highlighting its potential as a novel, liver-specific CT imaging agent (see figure).

KW - Computed tomography

KW - Gold

KW - Heparin

KW - Imaging agents

KW - Nanoparticles

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DO - 10.1002/chem.200902344

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VL - 15

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 48

ER -

Heparin-Coated gold nanopartieles for liver-Specific CT imaging

Abstract

Keywords

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